血清可溶性CD40L和CD147水平与短暂性脑缺血发作早期临床转归的相关性研究  

The Correlation Between Levels of Serum Soluble CD40L and CD147 andEarly Clinical Outcomes of Transient Ischemic Attack

作　　者：屈战利 王运峰 杨旭 王尚军 龙继发 季一飞 QU Zhanli;WANG Yunfeng;YANG Xu;WANG Shangjun;LONG Jifa;JI Yifei(Department of Neurology,Nanchong Central Hospital,Nanchong 637000,China)

机构地区：[1]南充市中心医院神经内科,四川南充637000

出　　处：《标记免疫分析与临床》2021年第7期1202-1205,1211,共5页Labeled Immunoassays and Clinical Medicine

基　　金：四川省基层卫生事业发展研究中心立项项目(编号:SWFZ19-C-71)。

摘　　要：目的研究血清可溶性CD40L(sCD40L)和CD147(sCD147)水平与短暂性脑缺血发作(TIA)早期临床转归的相关性。方法选择2017年3月至2020年3月就诊于我院的220例TIA患者,作为TIA组,观察全部TIA患者发病后第3个月内是否发生脑梗死,其中未发生脑梗死作为阴性组(n=179),发生脑梗死作为阳性组(n=41),根据ABCD3评分结果将全部TIA患者分为低危组(n=79)、中危组(n=103)和高危组(n=38),另选取于我院的90例健康体检者,作为对照组,比较各组入选对象血清sCD40L、sCD147水平,并分析sCD40L、sCD147与脑梗死发生率的相关性。结果TIA组血清sCD40L、sCD147水平明显高于对照组(P<0.05);中危组、高危组血清sCD40L、sCD147水平明显高于低危组(P<0.05),高危组血清sCD40L、sCD147水平明显高于中危组(P<0.05);阳性组血清sCD40L、sCD147水平明显高于阴性组(P<0.05);低危组脑梗死发生率为5.06%(4/79),中危组脑梗死发生率为20.39%(21/103),高危组脑梗死发生率为42.11%(16/38),sCD40L水平与脑梗死发生率呈正相关(r=0.575,P<0.001),sCD147水平与脑梗死发生率同样呈正相关(r=0.488,P<0.001),且危险等级越高,sCD40L、sCD147与脑梗死发生率的相关性越强。结论血清sCD40L、sCD147水平在TIA患者体内异常上升,且TIA危险等级越高,血清sCD40L、sCD147水平相应越高,较低水平的sCD40L、sCD147可能预示TIA患者良好的早期临床转归。Objective To study the correlation between levels of serum soluble CD40L(sCD40L)and CD147(sCD147)and early clinical outcomes of transient ischemic attack(TIA).Methods A total of 220 TIA patients who were admitted to our hospital from March,2017 to March,2020 were selected as the TIA group.Whether cerebral infarction occurred in TIA patients within 3 months after the disease onset was observed.Based on these results,patients without cerebral infarction were set as the negative group(n=179),while patients with cerebral infarction were included in the positive group(n=41).All TIA patients were divided into the low-risk group(n=79),middle-risk group(n=103)and high-risk group(n=38)according to the ABCD3 score results.Another 90 healthy people who had physical examination in our hospital were selected as the control group.The levels of serum sCD40L and sCD147 of each group were compared,and the correlation between sCD40L and sCD147 and incidence rate of cerebral infarction was analyzed.Results The levels of sCD40L and sCD147 in the TIA group were significantly higher than those in the control group(P<0.05).The levels of sCD40L and sCD147 in the middle-risk group and high-risk group were significantly higher than those in the low-risk group(P<0.05),and the levels of sCD40L and sCD147 in the high-risk group were significantly higher than those in the middle-risk group(P<0.05).The levels of sCD40L and sCD147 in the positive group were significantly higher than those in the negative group(P<0.05).The incidence rate of cerebral infarction was 5.06%(4/79)in the low-risk group,was 20.39%(21/103)in the middle-risk group,and was 42.11%(16/38)in the high-risk group.The sCD40L level was positively correlated with the incidence rate of cerebral infarction(r=0.575,P<0.001),and the sCD147 level was also positively correlated with incidence rate of cerebral infarction(r=0.488,P<0.001).The higher the risk level,the stronger the correlation between sCD40L and sCD147 and incidence rate of cerebral infarction.Conclusion The serum sCD40L

关 键 词：短暂性脑缺血发作 SCD40L sCD147 

分 类 号：R743.31[医药卫生—神经病学与精神病学]