阿那曲唑在乳腺癌术后化疗患者中的应用效果  

Effect of anatrazole on postoperative chemotherapy in patients with breast cancer

作　　者：付祖德 FU Zu-de(University of Chinese Academy of Science Shenzhen Hospital,Shenzhen 518106,China)

机构地区：[1]中国科学院大学深圳市医院,518106

出　　处：《中国现代药物应用》2021年第14期17-19,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究阿那曲唑在乳腺癌术后化疗患者中的应用效果。方法148例乳腺癌患者,根据术后化疗方法不同分为实验组和对照组,每组74例。对照组行常规化疗+他莫昔芬治疗,实验组行常规化疗+阿那曲唑治疗。比较两组患者治疗前后的血脂指标[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,肝功能指标[丙氨酸转氨酶(ALT)、谷氨酰转移酶(GGT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)]水平,不良反应发生情况。结果治疗后,实验组患者的TG、TC、LDL-C水平低于本组治疗前,HDL-C水平高于本组治疗前;对照组患者的LDL-C水平低于本组治疗前;且实验组患者的TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组;差异均具有统计学意义(P<0.05)。治疗后,两组患者的ALT、GGT、AST、TBIL水平均低于本组治疗前,且实验组患者的ALT(26.06±4.45)U/L、GGT(22.94±3.21)U/L、AST(27.29±2.31)U/L、TBIL(10.42±4.18)μmol/L均低于对照组的(28.66±3.41)U/L、(26.54±1.91)U/L、(30.19±4.38)U/L、(12.02±3.27)μmol/L,差异具有统计学意义(P<0.05)。两组患者的恶心呕吐、皮疹、腹泻、全身乏力不良反应发生率比较,差异均无统计学意义(P>0.05)。结论乳腺癌术后化疗患者行阿那曲唑辅助治疗,可明显改善患者的血脂及肝功能指标,临床疗效良好,值得推广。Objective To investigate the effect of anatrazole on postoperative chemotherapy in patients with breast cancer.Methods 148 patients with breast cancer were divided into an experimental group and a control group according to their postoperative chemotherapy methods,with 74 patients in each group.The control group was treated with routine chemotherapy combined with tamoxifen,while the experimental group was treated with routine chemotherapy combined with anatrozole.Level of blood lipid indexes[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)],level of liver function indexes[alanine transaminase(ALT),glutamyltranspeptidase(GGT),aspartate transaminase(AST),total bilirubin(TBIL)]and the incidence of adverse reactions prior and after treatment were compared between these two groups.Results For patients in the experimental group,levels of TG,TC and LDL-C after treatment were lower than those prior treatment,and the level of HDL-C after treatment was higher than that prior treatment.For patients in the control group,the level of LDL-C after treatment was lower than that prior treatment.After treatment,levels of TG,TC and LDL-C in the experimental group were lower than those in the control group,and the level of LDL-C in the experimental group was higher than that in the control group.The difference was statistically significant(P<0.05).Levels of ALT,GGT,AST,TBIL of patients in the two groups after treatment were lower than those of patients in its own group prior treatment.Patients in the experimental group had ALT of(26.06±4.45)U/L,GGT of(22.94±3.21)U/L,AST of(27.29±2.31)U/L,TBIL of(10.42±4.18)μmol/L,which were lower than(28.66±3.41)U/L,(26.54±1.91)U/L,(30.19±4.38)U/L,(12.02±3.27)μmol/L of patients in the control group.The difference was statistically significant(P<0.05).The difference in the incidence of adverse reactions,such as nausea and vomiting,rash,diarrhea and malaise,of patients between the two groups was not statistically significant(P>0.05).Conclusion Anatrazole-aide

关 键 词：乳腺癌 阿那曲唑 他莫昔芬 术后化疗 血脂 肝功能 

分 类 号：R737.9[医药卫生—肿瘤]