依达拉奉联合超早期溶栓治疗急性脑梗死患者的临床观察  

Clinical observation of edaravone combined with ultra-early thrombolysis in patients with acute cerebral infarction

作　　者：赵静 ZHAO Jing(Department of Internal Medicine,Panjin People’s Hospital,Panjin 124000,China)

机构地区：[1]盘锦市人民医院内科,124000

出　　处：《中国现代药物应用》2021年第14期107-109,共3页Chinese Journal of Modern Drug Application

摘　　要：目的评价急性脑梗死患者采取依达拉奉联合超早期溶栓治疗的预后效果。方法60例急性脑梗死患者作为研究对象,根据治疗方法不同分为对照组与联合组,各30例。对照组患者给予重组人组织型纤溶酶原激活物(rt-PA)静脉溶栓治疗,联合组患者在对照组基础上配合依达拉奉治疗。比较两组患者临床效果以及治疗前后的美国国立卫生研究院卒中量表(NIHSS)、Barthel指数(BI指数)评分。结果联合组治疗总有效率93.34%高于对照组的63.34%,差异具有统计学意义(P<0.05)。联合组治疗前NIHSS、BI指数评分分别为(8.6±1.3)、(44.5±3.9)分,治疗后分别为(3.1±1.0)、(83.3±6.8)分;对照组治疗前NIHSS、BI指数评分分别为(8.6±1.5)、(44.3±3.5)分,治疗后分别为(6.2±1.3)、(67.3±6.5)分。治疗前,两组患者NIHSS、BI指数评分比较,差异均无统计学意义(P>0.05);治疗后,两组患者NIHSS、BI指数评分均较治疗前有所改善,且联合组患者NIHSS、BI指数评分改善效果优于对照组,差异均具有统计学意义(P<0.05)。结论依达拉奉联合超早期溶栓治疗可以进一步促进急性脑梗死患者神经功能缺损改善、提高患者日常生活自理能力,整体临床疗效显著。Objective To evaluate the prognostic effect of edaravone combined with ultra-early thrombolysis in patients with acute cerebral infarction.Methods A total of 60 patients with acute cerebral infarction as study subjects were divided into control group and combined group according to different treatment methods,with 30 cases in each group.The control group was treated with recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis,and the combined group was treated with edaravone based on the control group.The clinical effect,National Institutes of Health stroke scale(NIHSS)score and Barthel index(BI)score before and after treatment were compared between the two groups.Results The total effective rate 93.34%of the combined group was higher than 63.34%of the control group,and the difference was statistically significant(P<0.05).In the combined group,the NIHSS score and BI score were(8.6±1.3)and(44.5±3.9)points before treatment,which were(3.1±1.0)and(83.3±6.8)points after treatment;in the control group,the NIHSS score and BI score before treatment were(8.6±1.5)and(44.3±3.5)points,which were(6.2±1.3)and(67.3±6.5)points after treatment.Before treatment,there was no statistically significant difference in NIHSS score and BI score between the two groups(P>0.05);after treatment,the NIHSS score and BI score of the two groups were better than those before treatment,and the NIHSS score and BI score of the combined group were better than those of the control group.All the difference was statistically significant(P<0.05).Conclusion Combination of edaravone and ultra-early thrombolysis can further improve the neurological deficit of patients with acute cerebral infarction,improve the self-care ability of patients,and the overall clinical effect is significant.

关 键 词：依达拉奉 超早期溶栓 急性脑梗死 神经缺损 自理能力 

分 类 号：R743.33[医药卫生—神经病学与精神病学]