健脾清热化湿法预防大肠息肉内镜下黏膜切除术后复发的研究  

Prevention of recurrence of colorectal polyps after endoscopic mucosal resection by Invigorating Spleen and Clearing away Heat and Dampness

作　　者：李小兰[1] 袁刚 朱俊张 吉峰 张国华[1] 王利兵[1] LI Xiaolan;YUAN Gang;ZHU Junzhang;JI Feng;ZHANG Guohua;WANG Libing(Department of Gastroenterology,Zhangjiagang Hospital of Traditional Chinese Medicine,Nanjing University of Traditional Chinese Medicine,Zhangjiagang,215600,China;Department of Geriatrics,Zhangjiagang Luyuan Hospital)

机构地区：[1]南京中医药大学附属张家港市中医医院消化内科,江苏张家港215600 [2]张家港鹿苑医院老年科

出　　处：《中国中西医结合消化杂志》2021年第7期460-463,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的:观察健脾清热化湿法预防大肠息肉内镜下黏膜切除术后复发的疗效。方法:入选患者按就诊序号用随机数字表法分为治疗组(143例),在健康生活指导基础上口服健脾清热化湿剂6周;对照组(143例)仅予健康生活指导,2年后复查肠镜,统计2组大肠息肉复发率及临床相关症状治疗前后积分。结果:治疗前,2组患者症状积分差异无统计学意义;治疗6周后,治疗组患者的症状积分均显著低于对照组(P<0.01);治疗2年后,治疗组复发率为14.7%,对照组为32.2%,治疗组复发率明显低于对照组(P<0.01)。2组术后第7天内镜下迟发性出血率比较差异无统计学意义。结论:大肠息肉内镜下黏膜切除术后口服健脾清热化湿剂能明显降低息肉复发率,并改善相关临床症状,但对息肉术后迟发性出血无明显治疗作用。Objective:To observe the effect of Invigorating Spleen and Clearing away Heat and Dampness on preventing the recurrence of colorectal polyp after endoscopic mucosal resection(EMR).Methods:The selected patients were divided into treatment group(143 cases)by random number table,on the basis of healthy life guidance,oral Invigorating Spleen and Clearing away Heat and Dampness agent for 6 weeks;the control group(143 cases)only received health life guidance,colonoscopy was repeated two years later,statistics the recurrence rate of colorectal polyp,incidence of delayed bleeding after EMR and the score of clinical symptoms.Results:There was no significant difference in symptom scores between the two groups before treatment,and after 6 weeks,the symptom scores in the treatment group were significantly lower than those in the control group(P<0.01);there was no significant difference in the incidence of delayed bleeding between the two groups;after 2 years,the recurrence rate was 14.7%in the treatment group and 32.2%in the control group,the therapeutic effect of the treatment group was better than that of the control group(P<0.01).Conclusion:Oral Invigorating Spleen and Clearing away Heat and Dampness agent after endoscopic mucosal resection of colorectal polyps can significantly reduce the recurrence rate of polyps and improve the related clinical symptoms.

关 键 词：健脾清热化湿法 大肠息肉 内镜下黏膜切除术 复发率 

分 类 号：R735.3[医药卫生—肿瘤]