Silver nanoislands on cellulose fibers for chromatographic separation and ultrasensitive detection of small molecules  

作　　者：Hyukjin Jung Moonseong Park Minhee Kang Ki-Hun Jeong 

机构地区：[1]Department of Bio and Brain Engineering,KAIST Institute for Optical Science and Technology,Korea Advanced Institute of Science and Technology,291 Daehak-ro,Yuseong-gu,Daejeon 305-701,Korea

出　　处：《Light(Science & Applications)》2016年第1期796-802,共7页光（科学与应用)（英文版）

基　　金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MEST)(2014022751,2014039957,2011-0031866);supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HI13C2181).

摘　　要：High-throughput small-molecule assays play essential roles in biomedical diagnosis,drug discovery,environmental analysis,and physiological function research.Nanoplasmonics holds a great potential for the label-free detection of small molecules at extremely low concentrations.Here,we report the development of nanoplasmonic paper(NP-paper)for the rapid separation and ultrasensitive detection of mixed small molecules.NP-paper employs nanogap-rich silver nanoislands on cellulose fibers,which were simply fabricated at the wafer level by using low-temperature solid-state dewetting of a thin silver film.The nanoplasmonic detection allows for the scalable quantification and identification of small molecules over broad concentration ranges.Moreover,the combination of chromatographic separation and nanoplasmonic detection allows both the highly sensitive fluorescence detection of mixed small molecules at the attogram level and the label-free detection at the sub-nanogram level based on surface-enhanced Raman scattering.This novel material provides a new diagnostic platform for the high-throughput,low-cost,and label-free screening of mixed small molecules as an alternative to conventional paper chromatography.

关 键 词：nanoplasmonics paper chromatography plasmon-enhanced spectroscopy silver nanoislands small-molecule assay 

分 类 号：R73[医药卫生—肿瘤]