溃疡汤联合雷贝拉唑治疗Hp相关性十二指肠溃疡的疗效及其对患者血清NF-κB与TNF-α的影响  

Efficacy of Ulcer Decoction Combined With Rabeprazole in the Treatment of hp-Associated Duodenal Ulcer and Its Effect on Serum NF-B and TNF-in Patients

作　　者：李晶 Li Jing(Department of Western Medicine,Nanyang First People's Hospital,Nanyang 473000 China)

机构地区：[1]南阳市第一人民医院西药科,河南南阳473000

出　　处：《哈尔滨医药》2021年第2期43-44,共2页Harbin Medical Journal

摘　　要：目的探讨溃疡汤联合雷贝拉唑治疗Hp相关性十二指肠溃疡的疗效及其对患者血清核因子κB(Nuclear factor kappa-B,NF-κB)与肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)的影响。方法按照随机数字表法,将96例Hp相关性十二指肠溃疡患者分为对照组与观察组,各48例。对照组给予基于雷贝拉唑肠溶片,联合克拉霉素片、阿莫西林胶囊治疗,观察组在此基础上联合中药汤剂溃疡汤治疗。比较两组疗效及治疗前后患者血清NF-κB与TNF-α水平。结果观察组临床总有效率为93.75%,显著高于对照组(77.08%)(P<0.05);两组患者治疗后较治疗前血清TNF-α、NF-κB水平均显著下降(P<0.05),且观察组血清上述2种指标水平下降幅度显著大于对照组(P<0.05);观察组Hp根除率为93.75%,显著高于对照组(72.92%)(P<0.05);观察组治疗后复发率为10.42%,显著低于对照组(18.75%)(P<0.05)。结论溃疡汤联合雷贝拉唑治疗Hp相关性十二指肠溃疡的疗效显著,可有效根除Hp、降低疾病复发率,降低患者血清NF-κB与TNF-α水平,具有临床可行性。Objective To investigate the efficacy of ulcer decoction combined with rabeprazole in the treatment of hp-associated duodenal ulcer and its effect on the serum Nuclear factor kappa-B(NF-B)and Tumor necrosis factor-(TNF-).Methods According to the random number table method,96 cases of hpa-associated duodenal ulcer patients admitted to the department of gastroenterology of our hospital were divided into control group and observation group,48 cases each.The control group was treated with rabeprazole enteric-coated tablets combined with clarithromycin tablets and amoxicillin capsules,and the observation group was treated with ulcer decoction based on rabeprazole enteric-coated tablets combined with clarithromycin tablets and amoxicillin capsules.Serum levels of NF-B and TNF-were compared before and after treatment.Results the total clinical effective rate of the observation group was 93.75%,significantly higher than that of the control group(77.08%)(P< 0.05).after treatment,the serum levels of TNF-and NF-B in both groups were significantly lower than those before treatment(P< 0.05),and the serum levels of the above two indicators in the observation group were significantly lower than those in the control group(P<0.05).the eradication rate of Hp in the observation group was 93.75%,significantly higher than that in the control group(72.92%)(P< 0.05).The recurrence rate of the observation group was 10.42%,significantly lower than that of the control group(18.75%)(P< 0.05).Conclusion Ulcer decoction combined with rabeprazole is effective in the treatment of hp-associated duodenal ulcer,which can effectively eradicate Hp,reduce the rate of disease recurrence,and reduce the serum levels of NF-B and TNF-in patients.

关 键 词：Hp相关性十二指肠溃疡 溃疡汤 雷贝拉唑 核因子ΚB 肿瘤坏死因子Α 

分 类 号：R573.3[医药卫生—消化系统]