Biomolecular network-based synergistic drug combination discovery:a combination of paeoniflorin and liquiritin alleviates neuropathic pain by inhibiting neuroinflammation via suppressing the chemokine signaling pathway  

作　　者：Qiuyan Guo Weijie Li Chao Wang Xia Mao Xiaoyue Wang Wenjia Chen Haiyu Xu Qian Wang Yanqiong Zhang Na Lin 

机构地区：[1]Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,100700 Beijing,China [2]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,100191 Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2020年第1期1804-1806,共3页信号转导与靶向治疗（英文）

基　　金：funded by the National Natural Science Foundation of China(81630107);National Key Research and Development Program of China(2019ZX09731-002 and 2018YFC1705201);Fundamental Research Funds for the Central Public Welfare Research Institute(Z2017082,L2017018,and ZXKT19013);the Key Laboratory of Beijing for the Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,China(BZ0328).

摘　　要：Dear Editor,Neuropathic pain(NP)resulting from injuries or diseases affecting the somatosensory nervous system is highly prevalent in various pathological conditions.1 Since NP is debilitating and impacts health and the quality of life,there is an urgent need for effective non-addictive new therapies.Traditional Chinese medicine(TCM)has been increasingly used for its benefits in relieving pain in clinics.Wu-Tou Decoction(WTD),which was first described by the famous TCM classic“Jin Gui Yao Lue”,is one of the most effective TCM herbal prescriptions for pain management.A growing body of clinical evidence shows that WTD markedly alleviates different types of NP,such as trigeminal neuralgia,inflammatory pain,and cancer-induced pain,with a total effectiveness of~80%.2 Our previous data demonstrated the analgesic effects of WTD via suppression of glial cell activation and neuroinflammation and further revealed that WTD attenuated NP partially by inhibiting spinal astrocytic IL-1R1/TRAF6/JNK signaling and regulating the glutamatergic system in CA3 in spinal nerve ligation(SNL)-induced NP in vivo.3,4 However,the bioactive compounds(BACs)of WTD that have an effect on NP and the underlying mechanisms remain unclear.

关 键 词：pain inflammation INHIBITING 

分 类 号：R285.5[医药卫生—中药学]