血清PGⅠ、PGⅡ、CEA水平及Hp检测在胃癌早期筛查中的应用  

Application of Serum PGⅠ,PGⅡ,CEA Levels and Hp Detection in the Early Screening of Gastric Cancer

作　　者：王晓健 郭守俊 曾庆芳 钟建明 WANG Xiaojian;GUO Shoujun;ZENG Qingfang;ZHONG Jianming(Ganzhou Cancer Hospital,Ganzhou 341000,China;不详)

机构地区：[1]江西省赣州市肿瘤医院,江西赣州341000

出　　处：《中国医学创新》2021年第20期124-127,共4页Medical Innovation of China

摘　　要：目的:探讨血清PGⅠ、PGⅡ、CEA水平及Hp检测在胃癌早期筛查中的应用。方法:选取2020年1-12月在本院确诊的92例胃癌患者为胃癌组,104例慢性胃炎患者为慢性胃炎组,104例胃溃疡患者为胃溃疡组。比较三组血清PGⅠ、PGⅡ、CEA水平及Hp阳性率。绘制ROC曲线并评估PGⅠ、PGⅡ、CEA和Hp在胃癌早期患者筛查中的应用价值。结果:胃癌组患者PGⅠ、PGⅡ水平均低于慢性胃炎组和胃溃疡组,CEA水平高于慢性胃炎组和胃溃疡组,差异均有统计学意义(P<0.05)。胃癌组、慢性胃炎组和胃溃疡组的Hp阳性率分别为92.39%、85.58%和79.81%,三组患者Hp阳性率比较,差异有统计学意义(P<0.05)。PGⅠ、PGⅡ、CEA及Hp预测胃癌发生的曲线下面积分别为0.768、0.721、0.796和0.608,低于PGⅠ、PGⅡ、CEA及Hp联合检测的0.867。结论:血清PGⅠ、PGⅡ、CEA水平及Hp检测对胃癌早期患者筛查具有临床价值。Objective:To explore the application of serum PGⅠ,PGⅡ,CEA levels and Hp detection in the early screening of gastric cancer.Method:A total of 92 gastric cancer patients diagnosed in our hospital from January to December 2020 were selected as the gastric cancer group,104 cases of chronic gastritis as the chronic gastritis group,and 104 cases of gastric ulcer as the gastric ulcer group.The levels of serum PGⅠ,PGⅡ,CEA and the positive rate of Hp were compared among the three groups.The ROC curve was drawn and the application value of PGⅠ,PGⅡ,CEA and Hp in the screening of early gastric cancer patients was evaluated.Result:The levels of PGⅠ,PGⅡ and CEA of gastric cancer group were lower than those of chronic gastritis group and gastric ulcer group,while CEA level was higher than those of chronic gastritis group and gastric ulcer group,the differences were statistically significant(P<0.05).The positive rates of Hp in gastric cancer group,chronic gastritis group and gastric ulcer group were 92.39%,85.58%and 79.81%,respectively,and the difference of Hp positive rates among the three groups was statistically significant(P<0.05).The area under the curve for predicting the occurrence of gastric cancer were 0.768,0.721,0.796 and 0.608 for PGⅠ,PGⅡ,CEA and Hp,respectively,which were lower than 0.867 for PGⅠ,PGⅡ,CEA and Hp combined detection.Conclusion:Serum PGⅠ,PGⅡ,CEA levels and Hp detection have clinical value in screening patients with early gastric cancer.

关 键 词：胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 癌胚抗原 幽门螺杆菌 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]