A microscale optical implant for continuous in vivo monitoring of intraocular pressure  

作　　者：Jeong Oen Lee Haeri Park Juan Du Ashwin Balakrishna Oliver Chen David Sretavan Hyuck Choo 

机构地区：[1]Department of Medical Engineering,California Institute of Technology,Pasadena,CA 91106,USA [2]Department of Electrical Engineering,California Institute of Technology,Pasadena,CA 91106,USA [3]Department of Ophthalmology,University of California San Francisco,San Francisco,CA 94143,USA [4]Department of Physiology,University of California San Francisco,San Francisco,CA 94143,USA

出　　处：《Microsystems & Nanoengineering》2017年第1期11-19,共9页微系统与纳米工程（英文）

基　　金：The project was funded by the National Institute of Health(NIH)EY024582;the Basic Science Research Program through the National Research Foundation of Korea(NRF)under the Ministry of Education(NRF-2013R1A6A3A03026384).

摘　　要：Intraocular pressure(IOP)is a key clinical parameter in glaucoma management.However,despite the potential utility of daily measurements of IOP in the context of disease management,the necessary tools are currently lacking,and IOP is typically measured only a few times a year.Here we report on a microscale implantable sensor that could provide convenient,accurate,ondemand IOP monitoring in the home environment.When excited by broadband near-infrared(NIR)light from a tungsten bulb,the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP.NIR light is minimally absorbed by tissue and is not perceived visually.The sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm Hg.Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits.Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.

关 键 词：GLAUCOMA intraocular pressure(IOP) microscale sensor implant in vivo continuous monitoring remote optical readout near-infrared(NIR)broadband light minimally invasive 

分 类 号：TG6[金属学及工艺—金属切削加工及机床]