High-fidelity replication of thermoplastic microneedles with open microfluidic channels  

作　　者：Zahra Faraji Rad Robert E.Nordon Carl J.Anthony Lynne Bilston Philip D.Prewett Ji-Youn Arns Christoph H.Arns Liangchi Zhang Graham J.Davies 

机构地区：[1]Graduate School of Biomedical Engineering,University of New South Wales,Sydney,NSW 2052,Australia [2]School of Mechanical Engineering,University of Birmingham,Birmingham B152TT,UK [3]School of Mechanical and Manufacturing Engineering,University of New South Wales,Sydney,NSW 2052,Australia [4]Prince of Wales Clinical School,University of New South Wales,Sydney,NSW 2052,Australia [5]School of Petroleum Engineering,University of New South Wales,Sydney,NSW 2052,Australia

出　　处：《Microsystems & Nanoengineering》2017年第1期96-106,共11页微系统与纳米工程（英文）

基　　金：CHA acknowledges the Australian Government for an ARC Future Fellowship(FT120100216);LEB was supported by an NHMRC senior research fellowship.

摘　　要：Development of microneedles for unskilled and painless collection of blood or drug delivery addresses the quality of healthcare through early intervention at point-of-care.Microneedles with submicron to millimeter features have been fabricated from materials such as metals,silicon,and polymers by subtractive machining or etching.However,to date,large-scale manufacture of hollow microneedles has been limited by the cost and complexity of microfabrication techniques.This paper reports a novel manufacturing method that may overcome the complexity of hollow microneedle fabrication.Prototype microneedles with open microfluidic channels are fabricated by laser stereolithography.Thermoplastic replicas are manufactured from these templates by soft-embossing with high fidelity at submicron resolution.The manufacturing advantages are(a)direct printing from computeraided design(CAD)drawing without the constraints imposed by subtractive machining or etching processes,(b)high-fidelity replication of prototype geometries with multiple reuses of elastomeric molds,(c)shorter manufacturing time compared to three-dimensional stereolithography,and(d)integration of microneedles with open-channel microfluidics.Future work will address development of open-channel microfluidics for drug delivery,fluid sampling and analysis.

关 键 词：drug delivery laser lithography MICRONEEDLES point-of-care diagnostics soft embossing 

分 类 号：TB3[一般工业技术—材料科学与工程]