铁死亡抑制蛋白1在人类疾病中的作用机制研究进展  

Research progress on role of ferroptosis suppressor protein 1 in human diseases

作　　者：陆会平[1] 党裔武[1] 陈罡[1] Lu Hui-Ping;Dang Yi-Wu;Chen Gang(Department of Pathology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院病理科,南宁530021

出　　处：《解放军医学杂志》2021年第7期731-736,共6页Medical Journal of Chinese People's Liberation Army

基　　金：广西研究生教育创新计划项目(YCBZ2020045,JGY2019050);广西医疗卫生适宜技术开发与推广应用项目(S2020031)。

摘　　要：铁死亡抑制蛋白1(FSP1)是新近被证实的铁死亡抑制因子,与乳腺癌、卵巢癌、肺癌、肝细胞癌、黑色素瘤、淋巴瘤、白血病、铜耐受、重症急性胰腺炎、糖尿病等疾病的发生发展密切相关。有研究发现,FSP1基于其氨基酸系列C末端片段、核易位、过表达等因素诱导非caspase依赖性的细胞凋亡,并可通过FSP1-CoQ_(10)-NAD(P)H途径、平行于经典的谷胱甘肽(GSH)-GPX4途径使细胞免于铁死亡,在细胞生命活动中发挥"双刃剑"的作用。该文综述目前FSP1在人类疾病中作用机制的研究进展,以期为疾病防治提供新的靶标。Ferroptosis suppressor protein 1(FSP1),confirmed as a ferroptosis-resistant factor recently,plays a key role in the oncogenesis and progress of human diseases,such as breast cancer,ovarian cancer,lung cancer,hepatocellular carcinoma,melanoma,lymphoma,leukemia,copper resistance,severe acute pancreatitis,and diabetes.FSP1 is regarded as a double-edged sword according to previous studies.Mechanically,FSP1 triggers caspase-independent apoptosis via its C-terminal fragments,nuclear translocation,or over-expression,and inhibits ferroptosis through FSP1-CoQ10-NAD(P)H axis,being independent of the glutathione(GSH)-GPX4 axis.The research progress in action mechanism of FSP1 in human diseases is briefly described in this review for providing novel preventative and therapeutic target molecules for human diseases.

关 键 词：铁死亡抑制蛋白1 凋亡诱导因子线粒体相关2 谷胱甘肽过氧化物酶4 铁死亡 

分 类 号：R364[医药卫生—病理学]