心肌分层应变技术评估纯合子型家族性高胆固醇血症患者主动脉瓣上狭窄左心室功能变化  

Evaluation of Left Ventricular Function in Patients of Homozygous Familial Hypercholesterolemia with Supra-aortic Stenosis by Myocardial Stratification Strain Technique

作　　者：周洁 徐丽媛 张芮英 潘宇帆 王绿娅 杨娅[1] Zhou Jie;Xu Liyuan;Zhang Ruiying;Pan Yufan;Wang Luya;Yang Ya(Department of Echocardiogrphy,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Department of Atherosclerosis,Beijing Institute of Heart Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院超声心动图室,北京市100029 [2]心肺血管研究所动脉硬化研究室,北京市100029

出　　处：《中国超声医学杂志》2021年第8期872-875,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金(No.81671686,81873896)。

摘　　要：目的探讨分层应变技术评估纯合子型家族性高胆固醇血症(HoFH)发生主动脉瓣上狭窄(SVAS)患者左心室功能的价值。方法入选确诊的HoFH患者57例,根据超声结果将其分为SVAS组(25例)和非SVAS组(32例)。采用EchoPAC软件获得左心室心内膜层整体纵向应变(GLSendo)、中层心肌整体纵向应变(GLSmyo)和心外膜层整体纵向应变(GLSepi)等指标进行统计学分析。分析两组患者心肌分层应变参数的变化。结果 SVAS组及非SVAS组GLSendo、GLSmyo、GLSepi呈梯度递减(P<0.05);SVAS组GLSendo、GLSmyo及GLSepi显著低于非SVAS组,差异有统计学意义(P<0.05)。结论心肌分层应变可早期准确评估HoFH患者发生SVAS左心室功能变化。Objective To investigate the value of myocardial stratified strain technique in assessing left ventricular function in patients with supra-aortic stenosis in homozygous familial hypercholesterolemia. Methods Fifty-seven homozygous familial hypercholesterolemia patients confirmed by Beijing Anzhen Hospital affiliated to Capital Medical University were selected. The patients were divided into supra-aortic stenosis group(25 cases) and non-supra-aortic stenosis group(32 cases) according to ultrasound results. The overall longitudinal strain of the endocardium, middle myocardium and epicardium of the left ventricle were obtained by EchoPAC software, and the parameters of GLSendo, GLSmyo, GLSepi were statistically analyzed. Results GLSendo, GLSmyo, GLSepi showed a gradient decrease in the SVAS group and non-SVAS group(P< 0.05).The longito and GLSepiudinal strain of GLSendo, GLSmyo and GLSepi in the supra-aortic stenosis group were significantly lower than that in the non-supra-aortic stenosis group, and the difference was statistically significant(P<0.05). Conclusions Myocardial stratification strain could accurately assess the left ventricular function of SVAS in patients with HoFH at an early stage.

关 键 词：纯合子 家族性高胆固醇血症 瓣上狭窄 应变 

分 类 号：R445.1[医药卫生—影像医学与核医学] R589.2[医药卫生—诊断学]