甲状腺乳头状癌患者血清中血管内皮生长因子的表达水平及其临床意义  

The expression and clinical significance of serum vascular endothelial growth factor in patients with papillary thyroid carcinoma

作　　者：张明 汪静 周详 李成 王喜青 ZHANG Ming;WANG Jing;ZHOU Xiang;LI Cheng;WANG Xiqing(Department of Nuclear Medicine,1st Affiliated Hospital of Air Force Military Medical University,Shaanxi Xi'an 710032,China)

机构地区：[1]空军军医大学第一附属医院核医学科,陕西西安710032

出　　处：《现代肿瘤医学》2021年第15期2612-2615,共4页Journal of Modern Oncology

摘　　要：目的:研究甲状腺乳头状癌(papillary thyroid carcinoma,PTC)及结节性甲状腺肿(nodular goiter,NG)患者血清中血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达情况及其对PTC淋巴结转移的诊断效能。方法:收集资料完整的PTC患者69例,选择20例NG患者作为良性对照,对两组患者血清VEGF水平进行比较,分析血清VEGF对PTC淋巴结转移的诊断效能,观察血清VEGF水平与BRAF^(V600E)基因突变在PTC中的关系,采用MACIS评分系统对PTC患者进行预后评估,并分析血清VEGF水平与预后指数的相关性。结果:VEGF在PTC患者血清中的水平明显高于NG患者,差异具有统计学意义(P<0.001);淋巴结转移患者血清VEGF水平高于无淋巴结转移患者,差异具有统计学意义(P=0.023);血清VEGF水平对于淋巴结转移的ROC曲线下面积(AUC)为0.689,灵敏度为0.698,特异性为0.750;血清VEGF水平与BRAF^(V600E)基因突变情况无显著相关性(P=0.177);血清VEGF水平与预后指数间不具有相关关系(r=0.065,P=0.600)。结论:血清VEGF能够有效区分PTC及NG,对PTC淋巴结转移具有一定的预测价值。Objective:To study the expression of VEGF in the serum of patients with papillary thyroid carcinoma(PTC)and nodular goiter(NG),and the diagnostic efficiency for PTC lymphatic metastasis.Methods:A total of 69 patients with complete PTC data were collected.20 patients with NG were selected as benign controls.Serum VEGF levels were compared with two groups.The diagnostic efficacy of serum VEGF in PTC lymphatic metastasis was analyzed.Serum VEGF levels and BRAF^(V600E) gene mutations were observed.The MACIS scoring system was used to evaluate the prognosis of PTC patients and the correlation between serum VEGF levels and prognosis index.Results:Serum VEGF levels were significantly higher in PTC patients than in NG patients(P<0.001).Serum VEGF levels in patients with lymphatic metastasis were higher than those without lymphatic metastasis(P=0.023).The area under the ROC curve(AUC)for lymphatic metastasis was 0.689.The sensitivity was 0.698,and the specificity was 0.750.There was no significant relationship between serum VEGF level and BRAF^(V600E) gene mutation(P=0.177).There was no correlation between serum VEGF level and prognosis indices(r=0.065,P=0.600).Conclusion:Serum VEGF can effectively distinguish papillary thyroid carcinoma(PTC)and nodular goiter(NG),which has certain predictive value of PTC lymphatic metastasis.

关 键 词：甲状腺乳头状癌 血管内皮生长因子 诊断效能 预后 

分 类 号：R736.1[医药卫生—肿瘤]