高脂饮食与阿尔茨海默病的研究进展  

Research Progress of High-Fat Diet and Alzheimer’s Disease

作　　者：黄颖 霍艳丽[2] 明越 郝军荣 HUANG Ying;HUO Yan-li;MING Yue;HAO Jun-rong(Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China;Basic Medical College,Hebei North University,Zhangjiakou,075000,China)

机构地区：[1]河北北方学院药学系,河北省神经药理学重点实验室,中国张家口075000 [2]河北北方学院基础医学院解剖教研室,中国张家口075000

出　　处：《神经药理学报》2020年第6期54-59,共6页Acta Neuropharmacologica

基　　金：河北省自然科学基金项目(No.H2019405057);河北省高等学校科学技术研究项目(No.ZD2020136)。

摘　　要：高脂饮食对阿尔茨海默病(Alzheimer’s disease,AD)的发病有着重要的作用,该文在总结AD可能的发病机制基础上,进一步阐述了高脂饮食导致AD发生的可能机制:增加血浆中饱和游离脂肪酸的含量,加快AD的病理进程;通过影响血脂水平促进AD的发生;导致大量脂肪的产生,并引起慢性炎症,产生的炎症因子穿过血脑屏障从而激发神经炎性细胞;高脂肪食物影响肠道菌群,进而影响到微生物群-大脑-肠道的轴,导致AD的产生。基于以上机制,可以从减少游离饱和脂肪酸、调节脂代谢紊乱、改善炎症、调节肠道菌群这些机制来治疗或者预防AD的发生。High-fat diet plays an important role in the pathogenesis of AD.This paper reviews the possible pathogenesis of Alzheimer’s disease in recent years,and further expounds the possible mechanism of high fat diet causing Alzheimer’s disease:High fat diet increases the content of saturated free fatty acids in plasma and speeds up the pathological process of AD;High fat diet promotes the occurrence of AD by influencing blood lipid levels;A high-fat diet will lead to the production of large amounts of fat and cause chronic inflammation,the inflammatory factors produced cross the blood-brain barrier and stimulate neuroinflammatory cells;High-fat food will affect the gut bacteria,which in turn affect the microbiota-brain-gut axis,then lead to the AD.Based on the above mechanisms,we can treat or prevent AD by reducing free saturated fatty acids,regulating lipid metabolism disorders,improving inflammation,and regulating intestinal flora.

关 键 词：高脂饮食 阿尔茨海默病 游离饱和脂肪酸 血脂 炎性因子 肠道菌群 

分 类 号：R964[医药卫生—药理学]