铁代谢在神经胶质瘤中的研究进展和应用  

Research Progress and Application of Iron Metabolism in Glioma

作　　者：王子豪 王立一 戴智博 范照鑫 杨世春[1] 王英炜[1] 崔英哲[1] 赵世光[1] 汪立刚[1] WANG Zihao;WANG Liyi;DAI Zhibo;FAN Zhaoxin;YANG Shichun;WANG Yingwei;CUI Yingzhe;ZHAO Shiguang;WANG Ligang(Department of Neurosurgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院神经外科,哈尔滨150001 [2]哈尔滨医科大学,哈尔滨150000

出　　处：《医学综述》2021年第14期2772-2776,共5页Medical Recapitulate

基　　金：高等学校博士学科点专项科研基金(新教师类)(20132307120028)。

摘　　要：神经胶质瘤是最常见的颅内恶性肿瘤,铁代谢在正常机体中具有重要作用,并与神经胶质瘤关系密切,而调控铁代谢的相关基因与低级别胶质瘤的生存期密切相关。线粒体铁蛋白通过介导小核仁RNA宿主基因1/miR-9-5p轴促进神经胶质瘤发生和血管生成。随着铁代谢相关胶质瘤诊断和治疗方式的逐渐应用,目前研究的铁螯合剂、维替泊芬、氧化铁纳米输送系统、青蒿素和5-氨基乙酰丙酸等可能是未来胶质瘤治疗的理想选择。Glioma is the most common intracranial malignant tumor.Iron metabolism plays an important role in normal body and is closely related to glioma.Iron metabolism related genes are closely related to the survival of low-grade gliomas.Mitochondrial ferritin promotes glioma genesis and angiogenesis by mediating small nucleolar RNA host gene 1/miR-9-5p axis.Along with the gradual application of iron metabolism-related glioma diagnosis and treatment methods,iron chelating agent,verteporfin,iron oxide nano-delivery system,artemisinin and 5-aminolevulinic acid may be ideal choices for glioma treatment in the future.

关 键 词：神经胶质瘤 铁代谢 铁螯合剂 超顺磁性氧化铁纳米颗粒 5-氨基乙酰丙酸 

分 类 号：R739.41[医药卫生—肿瘤]