食管腺癌动物模型建立方法的研究进展  

Research Progress of Establishment Methods of Animal Models of Esophageal Adenocarcinoma

作　　者：吴柳盛 刘继先[2] 乌达[2] 李小强 郑于臻 罗瑞星 徐鹏程 吴定旺 WU Liusheng;LIU Jixian;WU Da;LI Xiaoqiang;ZHEN Yuzhen;LUO Ruixing;XU Pengcheng;WU Dingwang(Peking University Shenzhen Hospital,Clinical College of Anhui Medical University,Shenzhen 518036,China;Department of Thoracic Surgery,Peking University Shenzhen Hospital,Shenzhen 518036,China;Anhui Medical University,Hefei 230032,China;Department of Thoracic Surgery,the Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China)

机构地区：[1]安徽医科大学北大深圳医院临床学院,广东深圳518036 [2]北京大学深圳医院胸外科,广东深圳518036 [3]安徽医科大学,合肥230032 [4]中山大学附属第六医院胸外科,广州510655

出　　处：《医学综述》2021年第14期2783-2788,共6页Medical Recapitulate

基　　金：广东省医学科学技术研究基金(A2020150)。

摘　　要：食管腺癌是严重威胁我国居民健康的一种常见胃肠道恶性肿瘤,明确其发病机制和生物学特征是临床研究的热点。目前食管腺癌模型构建方法主要有手术模拟构建法、化学致癌剂诱导法、原位移植构建法等,应用不同的肿瘤建模方法研究食管腺癌的发生机制和病理机制,有利于患者的早期诊疗和预后评估。可视化原位人源肿瘤模型能高度还原肿瘤生长的微环境,有效避免肿瘤患者个体间的差异,在耐药机制研究和临床预后评估中具有重要作用。然而关于食管腺癌的动物模型构建较少,因此构建一个理想的肿瘤动物模型至关重要。Esophageal adenocarcinoma is a common gastrointestinal malignancy that seriously threatens the health of Chinese residents.It is a hot spot of the clinical research to clarify the pathogenesis and biological characteristics.Currently,esophageal adenocarcinoma model construction methods include surgical simulation,chemical carcinogen induction,orthotopic transplantation,etc.Different tumor modeling methods are used to study the etiology and pathogenesis of esophageal adenocarcinoma,which is conducive to the early diagnosis and treatment,and prognosis evaluation.Patient-derived organoids-based xenograft visualization model can highly restore the microenvironment of tumor growth and effectively avoid the differences between individual patients,which plays an important role in drug resistance mechanism research and clinical prognosis evaluation.However,few animal models of esophageal adenocarcinoma have been constructed,so it is very important to construct an ideal animal model of the tumor.

关 键 词：食管腺癌 动物模型 种植肿瘤 原位人源肿瘤模型 

分 类 号：R735.1[医药卫生—肿瘤]