贝复舒滴眼液在病毒性角膜病中的应用效果  

Application effect of Beifushu eye drops in viral keratopathy

作　　者：程芳[1] 颜坚[1] 聂爱芹 CHENG Fang;YAN Jian;NIE Aiqin(Department of Ophthalmology,Shenzhen Longgang Central Hospital,Shenzhen,Guangdong 518116,China;Department of Ophthalmology,Shenzhen People's Hospital,Shenzhen,Guangdong 518020,China)

机构地区：[1]深圳市龙岗中心医院眼科,广东深圳518116 [2]深圳市人民医院眼科,广东深圳518020

出　　处：《现代医学与健康研究电子杂志》2021年第13期32-34,共3页Modern Medicine and Health Research

摘　　要：目的探究贝复舒滴眼液对病毒性角膜病患者房水中白介素-6(IL-6)、血管内皮生长因子(VEGF)水平的影响。方法选取深圳市龙岗中心医院2018年3月至2019年3月收治的60例病毒性角膜病患者作为研究对象,采用随机数字表法分为对照组(30例)与研究组(30例),对照组患者采用阿昔洛韦滴眼液治疗,研究组患者在对照组的基础上加用贝复舒滴眼液治疗,两组患者均以15 d为1个疗程,持续治疗3个疗程。比较两组患者治疗前后的眼压、泪腺分泌量、泪膜破裂时间、角膜荧光染色积分及房水中IL-6、VEGF水平,治疗期间不良反应发生情况。结果治疗后两组患者眼压、角膜荧光染色积分均较治疗前显著降低,且研究组显著低于对照组,泪腺分泌量较治疗前显著升高,且研究组显著高于对照组;泪膜破裂时间较治疗前显著延长,且研究组显著长于对照组;治疗后两组患者房水中IL-6、VEGF水平均较治疗前显著降低,且研究组显著低于对照组(均P<0.05);研究组患者治疗期间不良反应总发生率低于对照组,但差异无统计学意义(P>0.05)。结论贝复舒滴眼液治疗病毒性角膜病,可降低患者眼压及房水中的IL-6、VEGF水平,从而抑制病理新生血管的形成,改善患者临床症状,且不会增加不良反应,安全性良好。Objective To investigate the effect of Beifushu eye drops on the levels of interleukin-6(IL-6)and vascular endothelial growth factor(VEGF)in aqueous humor of patients with viral keratopathy.Methods A total of 60 patients with viral keratopathy who admitted to Shenzhen Longgang Central Hospital from March 2018 to March 2019 were selected as the research subjects.They were divided into the control group(30 cases)and the research group(30 cases)using to the random number table method.The patients in the control group were treated with acyclovir eye drops,and the patients in the research group were treated with Beifushu eye drops on the basis of the control group.Both groups took 15 days as a course of treatment and continued treatment for 3 courses.The intraocular pressure,lacrimal gland secretion,tear film rupture time,corneal fluorescence staining score and the levels of IL-6 and VEGF in aqueous humor were compared between the two groups before and after treatment,and the occurrence of adverse reactions during the treatment period was counted.Results After treatment,the intraocular pressure and corneal fluorescence staining scores of the two groups of patients were lower than before treatment,and the research group was lower than the control group;after treatment,the lacrimal gland secretion of the two groups increased compared with before treatment,and the research group was higher than the control group;after treatment,the tear break-up time lengthen significantly compared with before treatment,and the research group was longer than the control group;the levels of IL-6 and VEGF in aqueous humor of the two decreased compared with before treatment,and the research group was lower than that of the control group(all P<0.05);the total incidence of adverse reactions in the research group was lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion Befuxu eye drops can reduce the intraocular pressure and the levels of IL-6 and VEGF in aqueous humor of patients with vi

关 键 词：病毒性角膜病 贝复舒滴眼液 眼压 白介素-6 血管内皮生长因子 

分 类 号：R772.2[医药卫生—眼科]