核转录因子I-C在牙根发育中的作用  

Role of Nuclear Factor I-C in Tooth Root Development

作　　者：刘昕 谢晓华[1] LIU Xin;XIE Xiaohua(Department of Pediatric Sto-matology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二临床医学院儿童口腔科,黑龙江哈尔滨150086

出　　处：《口腔医学研究》2021年第8期689-692,共4页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:81600848);黑龙江省博士后面上项目(编号:LBH-Z19079)。

摘　　要：牙根发育是一个复杂的过程,由上皮和间充质共同调控完成,并涉及多种分子的相互作用。研究发现,核转录因子I-C(nuclear factor I-C,NFIC)是调控牙根发育的主要分子之一,NFIC参与根部牙本质的形成。牙根的生长是通过与多种分子相互作用实现的,这些分子包括转化生长因子-β(transforming growth factorβ,TGF-β)、Krüppel样转录因子4(Krüppel-like factor 4,KLF4)、Osterix(OSX)、Hedgehog(HH)、AFF4和微量元素锌等。本文将对NFIC在牙根形成过程中的作用和与NFIC相关的分子作一综述。Tooth root development is a complex process,which is jointly controlled by epithelium and mesenchyme and involves the interaction of multiple molecules.The study found that nuclear transcription factor I-C(NFIC)is one of the main molecules that regulate tooth root development.NFIC is involved in the formation of root dentin and root growth through interaction with various molecules including transforming growth factorβ(TGFβ),Krüppel-like factor 4(KLF4),osterix(OSX),hedgehog(HH),AFF4,and trace element zinc.This article will review the role of NFIC in tooth root formation and the molecules related to NFIC.

关 键 词：核转录因子I-C 牙根发育 成牙本质细胞 分子信号 

分 类 号：R394.1[医药卫生—医学遗传学]