血栓弹力图、凝血功能、D-二聚体、血小板聚集、同型半胱氨酸检测对急性脑卒中患者诊治价值  

Diagnostic and therapeutic value of thromboelastogram,coagulation function,D-dimer,platelet aggregation and homocysteine in patients with acute stroke

作　　者：黄越 苏平 谢代刚 HUANG Yue;SU Ping;XIE Daigang(Department of Emergency,the Fifth People's Hospital of Foshan,Guangdong,Foshan 528211,China)

机构地区：[1]广东省佛山市第五人民医院急诊科,广东佛山528211

出　　处：《中国医药科学》2021年第13期210-213,共4页China Medicine And Pharmacy

基　　金：广东省佛山市科技计划项目(2018AB000072)。

摘　　要：目的评价对急性脑卒中患者应用血栓弹力图、凝血功能、D-二聚体、血小板聚集(PAgT)、同型半胱氨酸(Hcy)检测的临床诊治价值。方法选取2017年1月至2019年12月期间我院共收治的急性脑卒中患者60例,根据患者疾病类型划定组别,甲组(n=34)为急性脑梗死患者,乙组(n=26)为急性脑出血患者。另选同时段至我院接受健康体检的健康对象32名纳入对照组。三组均接受血栓弹力图、凝血功能、D-二聚体、PAgT、Hcy检测,评价及比较三组的上述指标检测结果。结果三组的血栓弹力图指标比较,差异有统计学意义(P<0.05);三组的凝血酶原时间(PT)、活化部分凝血活酶原时间(APTT)比较,差异无统计学意义(P>0.05);甲组的纤维蛋白原(FBI)、血浆纤维蛋白原(FBG)、D-二聚体、PAgT、Hcy均高于对照组,差异有统计学意义(P<0.05);乙组的FBI、FBG、D-二聚体、Hcy均高于对照组,差异有统计学意义(P<0.05);乙组与对照组PAgT比较,差异无统计学意义(P>0.05)。结论对急性脑卒中患者应用血栓弹力图、凝血功能、D-二聚体、PAgT、Hcy检测,具有良好的诊断价值,可用于预后评估,从而为后续临床制订合适的诊疗计划提供可靠有力的理论依据,对病情转归具有积极意义。Objective To evaluate the clinical diagnostic and therapeutic value of thromboelastogram,coagulation function,D-dimer,platelet aggregation(PAgT)and homocysteine(Hcy)in patients with acute stroke.Methods A total of 60 patients with acute stroke admitted to and treated in our hospital from January 2017 to December 2019 were selected,and they were divided into group A(n=34)and group B(n=26)according to their disease types.Group A was patients with acute cerebral infarction,while group B was patients with acute cerebral hemorrhage.Other healthy subjects undergoing physical examination admitted to our hospital in the same period were included in the control group(n=32).All three groups were detected by thromboelastogram,coagulation function,D-dimer,PAgT and Hcy,and the results of the above indices were evaluated and compared.Results There was statistically significant difference in the index of thromboelastogram in the three groups(P<0.05).There were no statistically significant differences in prothrombin time(PT)and activated partial thromboplastin time(APTT)in the three groups(P>0.05).The levels of fibrinogen(FBI),plasma fibrinogen(FBG),D-dimer,PAgT and Hcy in group A were all higher than those in the control group,with statistically significant differences(P<0.05).The differences of FBI,FBG,D-dimer and Hcy in group B were all higher than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in PAgT between group B and the control group(P>0.05).Conclusion The application of thromboelastogram,coagulation function,D-dimer,PAgT and Hcy in patients with acute stroke has good diagnostic value.Therefore,it can be used for prognosis evaluation,so as to provide reliable and powerful theoretical basis for making appropriate diagnosis and treatment plans in the follow-up clinic.Meanwhile,it has positive significance for the prognosis of the disease.

关 键 词：急性脑卒中 血栓弹力图 凝血功能 D-二聚体 PAGT Hcy 

分 类 号：R743.3[医药卫生—神经病学与精神病学]