高危型人乳头瘤病毒分布特征与宫颈上皮内瘤变的关系研究  

Relationship between Distribution Characteristics of High-risk Human Papillomavirus and Cervical Intraepithelial Neoplasia

作　　者：陈莹莹[1] 钟守军[1] 刘祥玉[1] 代新珍 CHEN Yingying;ZHONG Shoujun;LIU Xiangyu;DAI Xinzhen(Department of Pathology,Bo'ai Hospital of Zhongshan City,Zhongshan 528400,China)

机构地区：[1]中山市博爱医院病理科,广东中山528400

出　　处：《中国医药指南》2021年第18期79-80,共2页Guide of China Medicine

摘　　要：目的研究高危型人乳头瘤病毒(HR-HPV)分布特征与宫颈上皮内瘤变(CIN)的关系。方法选取我院120例疑似CIN者,行HR-HPV检测。对HR-HPV检测结果呈阳性者予以宫颈薄层液基细胞学(TCT)检测,对TCT检测结果呈阳性者予以活检病理检测,统计活检病理检测结果及HR-HPV在CIN中阳性率及在CIN分型中分布特征。结果经病理检查结果显示,CIN 100例,其中CINⅠ33例,CINⅡ26例,CINⅢ41例,浸润性宫颈癌(ICC)20例;经HR-HPV、TCT检测结果显示,HR-HPV阳性率为88.33%(106/120);在CIN中常见HE-HPV分型为HPV16(30.19%)、HPV18(16.98%)、HPV52(20.75%)。结论HR-HPV分布特征与CIN具有紧密联系,临床需加强关注,予以有效干预,以降低癌症发生率。Objective To study the relationship between the distribution of high-risk human papillomavirus(HR-HPV)and cervical intraepithelial neoplasia(CIN).Methods Select 120 cases of suspected CIN in our hospital for HR-HPV testing.The patients with positive HR-HPV test were examined by cervical thin-layer liquid-based cytology(TCT).Biopsy pathological examination was performed on those with positive TCT test results,and the biopsy pathological test results and the positive rate of HR-HPV in CIN and the distribution characteristics in CIN classification were statistically analyzed.Results The pathological examination showed that there were 100 cases of CIN,including 33 cases of CINⅠ,26 cases of CINⅡ,41 cases of CINⅢ,and 20 cases of invasive cervical cancer(ICC).The results of HR-HPV and TCT showed that HR-The HPV positive rate was 88.33%(106/120);the common HE-HPV typing in CIN was HPV16(30.19%),HPV 18(16.98%),and HPV 52(20.75%).Conclusion The distribution of HR-HPV is closely related to CIN,the clinical need to strengthen attention and effective intervention to reduce the incidence of cancer.

关 键 词：高危型人乳头瘤病毒 宫颈上皮内瘤变 宫颈癌 宫颈癌前病变 

分 类 号：R737.33[医药卫生—肿瘤]