喹硫平联合碳酸锂治疗急性躁狂症43例疗效和对倍克-拉范森躁狂量表、注意力测评量表的评分影响  

Efficacy of Quetiapine Combined with Lithium Carbonate in the Treatment of Patients with Acute Mania and its Influence on BRMS and CPT

作　　者：张望杰 ZHANG Wangjie(Jiaozuo Psychiatric Hospital,Jiaozuo Henan 454000,China.)

机构地区：[1]焦作市精神病院,河南焦作454000

出　　处：《药品评价》2021年第12期760-762,共3页Drug Evaluation

摘　　要：目的:分析喹硫平联合碳酸锂治疗急性躁狂症患者的效果。方法:选取2017年2月至2020年2月焦作市精神病院急性躁狂症患者86例,按随机数字表法分为联合组43例和单一组43例,单一组采用碳酸锂治疗,联合组采用喹硫平联合碳酸锂治疗。对比两组疗效、不良反应和倍克-拉范森躁狂量表(BRMS)、注意力测评量表(CPT)评分。结果:联合组总有效率95.35%较单一组76.74%高(P<0.05);治疗后1周、治疗后2周,联合组PANSS、BRMS评分较单一组低(P<0.05);治疗后1周、治疗后2周,联合组CPT评分较单一组高(P<0.05);联合组不良反应发生率6.98%较单一组23.26%低(P<0.05)。结论:急性躁狂症患者采用喹硫平联合碳酸锂治疗可提高临床疗效,改善躁狂症状,安全性高。Objective:To analyze the effect of quetiapine combined with lithium carbonate in the treatment of patients with acute mania.Methods:86 patients with acute mania in Jiaozuo Psychiatric Hospital from February 2017 to February 2020 were selected and randomly divided into the combined group(43 cases)and the single group(43 cases).The single group was treated with lithium carbonate,and the combined group was treated with quetiapine combined with lithium carbonate.The efficacy,adverse reactions,BRMS and CPT scores were compared between the two groups.Results:The total effective rate of the combined group was 95.35%higher than 76.74%of the single group(P<0.05);the PANSS and BRMS scores of the combined group were lower than those of the single group 1 week and 2 weeks after treatment(P<0.05);the CPT score of the combined group was higher than that of the single group 1 week and 2 weeks after treatment(P<0.05);the incidence of adverse reactions of the combined group was 6.98%lower than that of the single group 23.26%(P<0.05).Conclusion:Quetiapine combined with lithium carbonate in the treatment of patients with acute mania can improve the clinical efficacy and manic symptoms,with high safety.

关 键 词：双相情感障碍 碳酸锂 喹硫平 躁狂症 认知功能 注意力 

分 类 号：R749.4[医药卫生—神经病学与精神病学]