高压氧联合头孢呋辛纳治疗放射性颌骨骨髓炎的临床疗效分析  

Clinical Effect of Hyperbaric Oxygen Combined with Drugs in Adjuvant Treatment of Radioactive Osteomyelitis of Jaws

作　　者：曾柳 江燕[1] 黄仁财 邓四海 张俊 ZENG Liu;JIANG Yan;HUANG Rencai;DENG Sihai;ZHANG Jun(Pingxiang People's Hospital,Pingxiang Jiangxi 337000,China.)

机构地区：[1]萍乡市人民医院,江西萍乡337000

出　　处：《药品评价》2021年第12期766-768,共3页Drug Evaluation

基　　金：江西省卫生健康委科技计划(202140528)。

摘　　要：目的:探究高压氧加药物治疗放射性颌骨骨髓炎的临床疗效。方法:选取萍乡市人民医院2018年1月至2019年12月收治的放射性颌骨骨髓炎患者80例,简单随机分为对照组和观察组各40例。对照组采用头孢呋辛纳进行治疗;观察组采用高压氧加头孢呋辛纳辅助进行治疗。比较两组临床疗效、愈合情况、临床症状缓解时间、治疗前后血氧含量及不良反应。结果:治疗后观察组总有效率为87.50%,对照组总有效率为67.50%,观察组明显高于对照组(P<0.05);治疗后观察组临床症状张口受限、感染、剧烈疼痛、反复溢脓及其他不良症状缓解时间均低于对照组(P<0.05);治疗后两组1年随访愈合率观察总有效率为97.50%,明显高于对照组82.50%(P<0.05),两组3个月后随访愈合率差异,无统计学意义(P>0.05);治疗后观察组与对照组血氧弥散及氧含量指标血氧饱和度(SpO2)、二氧化碳分压(PaCO2)、氧分压(PaO2)含量均有所上升,且观察组明显高于对照组(P<0.05);治疗后不良反应过敏、药物热、腹痛、头痛等发生情况差异无统计学意义(P>0.05)。结论:高压氧联合头孢呋辛纳治疗放射性颌骨骨髓炎疗效显著,为临床治疗放射性颌骨骨髓炎提供了新的选择和思路。Objective:To explore the clinical effect of hyperbaric oxygen combined with drugs in adjuvant treatment of radioactive osteomyelitis of jaws.Methods:A total of 80 RO Jpatients admitted to Pingxiang People's Hospital from January 2018 to December 2019 were enrolled and divided into control group and observation group according to simple random grouping method,40 cases in each group.The control group was treated with cefuroxime,while observation group was treated with hyperbaric oxygen and cefuroxime.The clinical curative effect,healing status,relief time of clinical symptoms,content of blood oxygen before and after treatment and adverse reactions were compared between the two groups.Results:After treatment,total response rate in observation group was significantly higher than that in control group(87.50%vs 67.50%)(P<0.05).After treatment,relief time of clinical symptoms(restriction of mouth opening,infection,severe pain,repeated pyorrhea)in observation group was shorter than that in control group(P<0.05).After treatment,healing rate in observation group was significantly higher than that in control group after 1year of follow-up(97.50%vs 82.50%)(P<0.05),but there was no significant difference in the healing rate between the two groups after 3 months of follow-up(P>0.05).After treatment,indexes of blood oxygen diffusion and oxygen content blood oxygen saturation(SpO2),partial pressure of carbon dioxide(PaCO2),partial pressure of oxygen(PaO2)in both groups were increased,which were significantly higher in observation group than control group(P<0.05).After treatment,there was no significant difference in the incidence of adverse reactions(allergies,drug fever,abdominal pain,headache)between the two groups(P>0.05).Conclusion:The effect of hyperbaric oxygen combined with drugs is significant in adjuvant treatment of ROJ,which provides new options and ideas for the clinical treatment of ROJ.

关 键 词：放射性骨坏死 颌骨骨髓炎 高压氧 放射性 辐射损伤 

分 类 号：R782.3[医药卫生—口腔医学]