免疫检查点抑制剂在晚期胆系恶性肿瘤中的研究进展  

Research progress of immune checkpoint inhibitors in advanced biliary tract cancers

作　　者：靖超 邓薇[1] 杨小宝 张忠涛[2] Jing Chao;Deng Wei;Yang Xiaobao;Zhang Zhongtao(Department of General Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of General Surgery,Beijing Friendship Hospital,Capital Medical University National Clinical Research Center for Digestive Diseases,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院普外科,100050 [2]首都医科大学附属北京友谊医院普外科,国家消化系统疾病临床医学研究中心,100050

出　　处：《国际外科学杂志》2021年第7期478-483,共6页International Journal of Surgery

摘　　要：胆系恶性肿瘤(BTC)是一系列罕见的恶性肿瘤,总体预后较差。根治性手术是首选的治疗方法,但是大多数患者在诊断时已经失去了手术机会。目前,胆道癌的系统治疗选择有限,且疗效差,反应时间短。在过去的几年中,免疫检查点抑制剂(ICIs)治疗已被确立为许多实体瘤和血液肿瘤的有效全身治疗选择。ICIs治疗胆道癌的研究一直在不断进行,并证明了其抗肿瘤的功效和安全性。然而,鉴于BTC的低发生率和高异质性,需要进行更多的临床试验和实践,并且需要探索包括ICIs和预测性生物标志物的有效组合方案。本文回顾并归纳近年BTC的ICIs治疗相关的临床研究,并归纳目前尚在进行的临床研究。与此同时,本文对近年国内外研究所提出的ICIs预测性生物学标志物进行归纳及总结。Biliary tract cancer(BTC)is a series of rare malignancies with poor overall prognosis.Radical surgery the preferred treatment option,but most patients have lost the opportunity of surgery at the time of diagnosis.At present,there are limited systematical treatment options for biliary tract cancers,and such treatments have poor efficacy and short duration of responses.In the past few years,immune checkpoint inhibitor therapy has been established as an effective systemic therapy option for many solid tumors and hematological tumors.The research for biliary tract cancer treated by of immune checkpoint inhibitors has been continuously carried out and demonstrated the anti-tumor efficacy and safety.However,in view of the low incidence and high heterogeneity of BTC more large number of clinical trials and practices need to be carried out,and the effective combination regimens and predictive biomarkers are urgent to be explored.This article reviews the recent clinical studies on immune checkpoint inhibitors for biliary tract cancer,and summarizes the ongoing clinical studies.At the same time,the predictive biomarkers of immune checkpoint inhibitors proposed by domestic and foreign researches in recent years are summarized.

关 键 词：胆道肿瘤 免疫抑制剂 胆系恶性肿瘤 免疫治疗 免疫检查点抑制剂 

分 类 号：R735.8[医药卫生—肿瘤]