Ⅲ型纤连蛋白样包含结构域1蛋白在食管癌组织中的表达及临床意义  

Expression ofⅢtype fibronectin like inclusion domain 1 protein in esophageal carcinoma and its clinical significance

作　　者：袁庆锋[1] 张琪[1] 杨云杰 YUAN Qingfeng;ZHANG Qi;YANG Yunjie(Department of Thoracic Srugery,Bazhong Central Hospital,Sichuan Province,Bazhong 636000,China)

机构地区：[1]四川省巴中市中心医院胸心外科,四川巴中636000

出　　处：《中国医药导报》2021年第19期40-43,F0004,共5页China Medical Herald

基　　金：四川省卫生和计划生育委员会科研项目(17P0163)

摘　　要：目的研究Ⅲ型纤连蛋白样包含结构域1(FNDC1)蛋白在食管癌组织中的表达及临床意义。方法应用免疫组化及实时荧光定量PCR检测四川省巴中市中心医院2013年4月至2015年4月诊治的93例食管癌患者癌组织及癌旁组织中FNDC1的表达,分析癌组织中FNDC1的表达与临床病理特点关系。随访5年,Kaplan-Meier生存分析癌组织中不同FNDC1表达患者预后的差异。结果癌组织中FNDC1 mRNA的相对表达量明显高于癌旁组织(P <0.05)。FNDC1阳性棕褐色染色主要位于癌组织中肿瘤细胞的细胞浆,癌组织中FNDC1的阳性表达率明显高于癌旁组织(P <0.05)。癌组织中FNDC1蛋白表达与肿瘤分期及淋巴结转移有关(P <0.05)。随访3~60个月,FNDC1阳性患者5年总体生存率低于FNDC1阴性患者(P <0.05),FNDC1阳性患者的平均生存时间短于FNDC1阴性患者(P <0.05)。结论食管癌组织中FNDC1表达升高,FNDC1的表达与肿瘤分期及淋巴结转移有关,并有可能成为判断食管癌患者生存预后的标志物。Objective To investigate the expression ofⅢtype fibronectin like inclusion domain 1(FNDC1)protein in esophageal carcinoma and its clinical significance.Methods Immunohistochemistry and real-time quantitative PCR were used to detect the expression of FNDC1 in cancer tissues and paracancerous tissues of 93 patients with esophageal cancer who were diagnosed and treated in Bazhong Central Hospital of Sichuan Province from April 2013 to April 2015.The relationship between the expression of FNDC1 and the clinicopathological characteristics in cancer tissues was analyzed.After five years of follow-up,the difference in prognosis of patients with different FNDC1 expression in cancer tissues by survival was analyzed Kaplan-Meier.Results The relative expression level of FNDC1 mRNA in cancer tissues was significantly higher than that in adjacent tissues(P<0.05);the positive staining of FNDC1 was mainly located in the cytoplasm of tumor cells in cancer tissues,and the positive expression rate of FNDC1 in cancer tissues was significantly higher than that in adjacent tissues(P<0.05).The expression of FNDC1 protein in cancer tissues was correlated with tumor stage and lymph node metastasis(P<0.05).Follow-up was 3-60 months,the 5-year overall survival rate of FNDC1 positive patients was significantly lower than that of FNDC1 negative patients(P<0.05),and the mean survival time of FNDC1 positive patients was significantly shorter than that of FNDC1 negative patients(P<0.05).Conclusion The expression of FNDC1 is increased in esophageal cancer tissues,and the expression of FNDC1 is related to tumor stage and lymph node metastasis,and may become a marker to judge the survival prognosis of patients with esophageal cancer.

关 键 词：食管癌 Ⅲ型纤连蛋白样包含结构域1 临床病例参数 预后 

分 类 号：R735.1[医药卫生—肿瘤]