非糖尿病急性缺血性脑卒中患者血浆ApoB/ApoA1比值的检测及其临床意义  

Detection and clinical significance of plasma ApoB/ApoA1 ratio in non-diabetic patients with acute ischemic stroke

作　　者：易晓净[1] 李乐军 YI Xiaojing;LI Lejun(Department of Encephalopathy,Wuxi Hospital of Traditional Chinese Medicine,Jiangsu Province,Wuxi 214000,China)

机构地区：[1]江苏省无锡市中医医院脑病科,江苏无锡214000

出　　处：《中国医药导报》2021年第19期98-101,共4页China Medical Herald

基　　金：江苏省卫生计生委科研课题项目(H2018035)。

摘　　要：目的观察非糖尿病急性缺血性脑卒中血浆载脂蛋白B与载脂蛋白A1比值(ApoB/ApoA1)的临床意义。方法选取2017年7月至2019年7月在江苏省无锡市中医医院(以下简称"我院")住院治疗的78例非糖尿病急性缺血性脑卒中患者作为脑卒中组,选取我院同期体检的55名体检结果健康者作为对照组,比较两组Apo B/ApoA1比值,采用logistic回归分析非糖尿病急性缺血性脑卒中发生的危险因素,绘制ApoB/ApoA1诊断非糖尿病急性缺血性脑卒中价值的受试者工作特征(ROC)曲线。结果脑卒中组ApoA1水平低于对照组,脑卒中组ApoB/ApoA1比值高于对照组,差异均有统计学意义(均P <0.05)。多因素logistic回归分析显示,ApoB/ApoA1比值升高、ApoA1水平降低为非糖尿病急性缺血性脑卒中的独立危险因素(P <0.05);ROC曲线分析显示,Apo B/ApoA1比值诊断非糖尿病急性缺血性脑卒中的曲线下面积为0.876,95%CI:0.714~0.922,灵敏度为69.1%,特异度为95.2%,最佳截断值为0.853。结论 ApoB/ApoA1比值升高是非糖尿病急性缺血性脑卒中患者的危险因素,外周血中ApoB/ApoA1的比值>0.853时,患非糖尿病急性缺血性脑卒中的风险大大增加。Objective To observe the clinical significance of the ratio of plasma apolipoprotein B to apolipoprotein A1(ApoB/ApoA1)in non-diabetic acute ischemic stroke.Methods A total of 78 cases of non-diabetic acute ischemic stroke patients hospitalized in Wuxi Hospital of Traditional Chinese Medicine(hereinafter referred to as“our hospital”)from July 2017 to July 2019 were selected as the stroke group,and 55 healthy subjects with physical examination results in our hospital during the same period were selected as the control group.The ratio of ApoB/ApoA1 in the two groups was compared,and the risk factors of non-diabetic acute ischemic stroke were analyzed by logistic regression,and the receiver operating characteristic(ROC)curve of the value of ApoB/ApoA1 in the diagnosis of non-diabetic acute ischemic stroke was drawn.Results The ApoA1 level in the stroke group was lower than that in the control group,and the ApoB/ApoA1 ratio in the stroke group was higher than that in the control group,with statistical significance(all P<0.05).Multivariate logistic regression analysis showed that the increase of ApoB/ApoA1 ratio and the decrease of ApoA1 level were independent risk factors for non-diabetic acute ischemic stroke(P<0.05).ROC curve analysis showed that the area under the curve of ApoB/ApoA1 ratio in the diagnosis of non-diabetic acute ischemic stroke was 0.876,95%CI:0.714-0.922,the sensitivity was 69.1%,the specificity was 95.2%and the best cutoff value was 0.853.Conclusion The increase of ApoB/ApoA1 ratio is a risk factor for patients with non-diabetic acute ischemic stroke.When the ratio of ApoB/ApoA1 in peripheral blood is higher than 0.853,the risk of non-diabetic acute ischemic stroke is greatly increased.

关 键 词：载脂蛋白B 载脂蛋白A1 急性缺血性脑卒中 动脉硬化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]