脑卒中后抑郁与卒中后认知障碍的关系研究  

Study on relationship between post-stroke depression and post-stroke cognitive impairment

作　　者：陆毅[1] 李海华[1] 余建伟[1] 陈甜[1] 梁洪涛[1] LU Yi;LI Haihua;YU Jianwei;CHEN Tian;LIANG Hongtao(Department of Neurology,Hechuan District People′s Hospital of Chongqing,Chongqing 401520,China)

机构地区：[1]重庆市合川区人民医院神经内科,重庆401520

出　　处：《现代医药卫生》2021年第15期2577-2579,2585,共4页Journal of Modern Medicine & Health

基　　金：重庆市卫生健康委员会区县医疗卫生学术技术带头人项目(2020-222-78)。

摘　　要：目的探讨脑卒中后抑郁(PSD)与卒中后认知障碍(PSCI)的关系。方法对2018年1月至2020年6月该院收治的256例脑卒中患者分别于入院第1、4周采用汉密尔顿抑郁量表和蒙特利尔认知功能评估量表进行抑郁程度和认知功能评估,并将有抑郁的患者设为轻度抑郁组(85例)、中度抑郁组(45例)和重度抑郁组(17例)。结果256例患者第1周PSD发生率为25.78%(66/256),第4周为31.64%(81/256);第1周PSCI发生率为40.23%(103/256),第4周为49.22%(126/256)。PSD组患者第1周PSCI发生率为69.70%(46/66),第4周为76.54%(62/81),明显高于非PSD组[分别为30.00%(57/190)、36.57%(64/175)],PSD组患者PSCI发生率明显高于非PSD组,且PSCI程度更重;脑卒中患者抑郁程度越重认知功能受损越明显;PSCI组患者汉密尔顿抑郁量表评分明显高于非PSCI组。结论PSD与患者认知功能受损有关,且相互影响。Objective To explore the relationship between post-stroke depression(PSD)and post-stroke cognitive impairment(PSCI).Methods A total of 256 inpatients with stroke treated in this hospital from January 2018 to June 2020 were evaluated by Hamilton Depression Scale(HAMD)and Montreal Cognitive Function Assessment Scale(MoCA)in the first,fourth week after admission.The patients with depression were set as the mild depression group(85 cases),moderate depression group(45 cases)and severe depression group(17 cases).Results Among 256 cases,the incidence rate of PSD was 25.78%(66/256)in the first week and 31.64%(81/256)in the fourth week;the incidence rate of PSCI in the first week was 40.23%(103/256)and 49.22%(126/256)in the fourth week;the incidence rate of PSCI in the PSD group was 69.70%(46/66)in the first week and 76.54%(62/81)in the fourth week,which were significantly higher than 30.00%(57/190)and 36.57%(64/175)in the non-PSD group.The incidence of PSCI in the PSD group was significantly higher than that in the non-PSD group,and the degree of PSCI was more serious;The more severe the degree of depression in stroke patients,the more obvious the impairment of cognitive function.The HAMD score of the PSCI group was significantly higher than that of the non-PSCI group.Conclusion PSD is related to the cognitive impairment in the patients,moreover they influence each other.

关 键 词：卒中 卒中后抑郁 卒中后认知障碍 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.41[医药卫生—临床医学]