厚朴排气合剂对直肠癌根治术后患者炎症因子和康复进程的影响  

Effect of Houpu Exhaust Mixture on Inflammatory Factor and Rehabilitation Process of Patients With Rectal Cancer After Radical Operation

作　　者：卢春颜[1] 陈婧霖 LU Chun-yan;CHEN Jing-lin(Baiyun District Traditional Chinese Medicine Hospital of Guangzhou City,Guangzhou Guangdong 510470;The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou Guangdong 510000)

机构地区：[1]广州市白云区中医医院,广东广州510470 [2]广州医科大学附属第二医院,广东广州510000

出　　处：《世界中西医结合杂志》2021年第7期1333-1336,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：广东省中医药局科研课题(20141035)。

摘　　要：目的探讨厚朴排气合剂对直肠癌根治术后患者炎症因子和康复进程的影响。方法选取2016年5月—2018年5月收治的直肠癌根治术患者106例,根据随机数字表法分成对照组和观察组,每组53例。对照组于术后给予常规治疗,观察组在对照组基础上加用厚朴排气合剂。比较两组患者胃肠功能恢复效果,包括肠鸣音恢复时间、肛门排气时间、首次进食时间、首次排便时间。比较两组患者中医证候积分及疗效,分别在治疗前、治疗4周后评价两组患者腹胀满、食少纳呆、大便不畅、恶心呕吐积分的变化。于治疗前、治疗1周后采血检测血清白介素-6(Interleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-α(Tumor necrosis factor-alpha,TNF-α)水平,记录住院期间并发症发生率。结果观察组肠鸣音恢复、肛门排气、首次进食、首次排便时间明显短于对照组,差异有统计学意义(P<0.05)。观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后腹胀满、食少纳呆、大便不畅、恶心呕吐积分及总分低于本组治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后血清IL-6、IL-8、TNF-α水平低于本组治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者肺部感染、切口感染、切口疝、吻合口瘘发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗基础上加用厚朴排气合剂,能进一步促进直肠癌根治术后患者胃肠功能恢复,提升疗效,减轻炎症,总体疗效良好。Objective To investigate the effect of Houpu Exhaust Mixture on inflammatory factors and rehabilitation process of patients with rectal cancer after radical operation.Methods 106 patients with rectal cancer treated in our hospital from May 2016 to May 2018 were divided into control group(n=53)and observation group(n=53)according to random number table method.The control group was given routine treatment after operation,while the observation group was given Houpu Exhaust Mixture on the basis of the control group.The recovery effects of gastrointestinal function after operation were compared between the two groups,including the recovery time of bowel sounds,the time of anal exhaust,the time of first eating and the time of first defecation.Before and after 4 weeks of treatment,the changes of abdominal distention,less food,poor stool,nausea and vomiting scores were evaluated.Serum levels of interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-alpha(TNF-α)were measured before treatment and 1 week after treatment.Record the incidence of complications during hospitalization.Results The recovery of bowel sounds,anal exhaust,first meal,and first defecation time in the observation group were significantly shorter than those in the control group(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,abdominal distension,poor appetite,poor appetite,poor bowel movements,nausea and vomiting,and total score were lower in the two groups than before treatment,and the observation group was significantly lower than the control group(P<0.05).Serum IL-6,IL-8,and TNF-αlevels after treatment in the two groups were lower than those before treatment in the two groups,and the observation group was lower than those in the control group(P<0.05).There was no significant difference in the incidence of lung infection,incisional infection,incisional hernia,and anastomotic leakage between the two groups(P>0.05).Conclusion On the basis conventional tr

关 键 词：直肠癌根治术 厚朴排气合剂 炎症因子 并发症 

分 类 号：R735.34[医药卫生—肿瘤]