《2020 ESC/HFA血清生物标志物在癌症治疗中心脏毒性监测中的作用声明》解读  

《2020 ESC/HFA Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies》:What is new?

作　　者：张新鑫 张艳丽[1] 方凤奇[2] 刘基巍[2] 夏云龙[1] 刘莹[1] Zhang Xinxin;Zhang Yanli;Fang Fengqi;Liu Jiwei;Xia Yunlong;Liu Ying(Department of Cardiology,First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;Department of Oncology,First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学附属第一医院心内科,大连116011 [2]大连医科大学附属第一医院肿瘤科,大连116011

出　　处：《中华检验医学杂志》2021年第7期652-656,共5页Chinese Journal of Laboratory Medicine

摘　　要：血清生物标志物作为心血管疾病诊断的重要工具,近年来在癌症患者基线风险评估中的价值日益凸显,由美国心力衰竭协会(HFA)肿瘤心脏病学研究小组与欧洲心脏病学会(ESC)肿瘤心脏病学委员会联合提出的《血清生物标志物在癌症治疗中心脏毒性监测中的作用立场声明》指出,通过评估心肌生物标志物在具有心脏毒性癌症治疗的患者中的特点,讨论2个主要的生物标志物即心肌肌钙蛋白和利钠肽在癌症治疗中发生心脏毒性反应的机制、临床应用、监测及预后。该声明目的是帮助多学科协作诊疗提供一个临床框架,依据危险分层指导临床医生选择合适的血清生物标志物监测方案,预防癌症患者发生心血管疾病。Detection of serum biomarkers is an important strategy for the diagnosis of cardiovascular diseases.The roles of serum biomarker detection have become increasingly valuable in the baseline risk stratification among cancer patients in recent years.The Cardio-oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology newly proposed the“role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies”.By evaluating the characteristics of cardiac biomarkers in cancer patients receiving cardiotoxic cancer therapy,this statement discussed the mechanism,clinical application,value on monitoring and prognosis of the two main biomarkers,cardiac troponin and natriuretic peptide on chemotherapy induced cardiac toxic responses.The purpose of this statement is to help establish the multidisciplinary collaborative diagnosis and treatment strategies and provide a clinical framework,and guide clinicians to select appropriate serum biomarker monitoring programs based on risk stratification to prevent cardiovascular disease in cancer patients.

关 键 词：肿瘤心脏病学 生物学标记 

分 类 号：R730.5[医药卫生—肿瘤]