前列地尔治疗急性脑梗死150例效果观察  

Effect of alprostadil on acute cerebral infarction in 150 cases

作　　者：汪飞[1] Wang Fei(Department of Neurology,The First People's Hospital of Jiashan,Jiaxing 314100,Zhejiang Province,China)

机构地区：[1]浙江省嘉善县第一人民医院神经内科,314100

出　　处：《中国基层医药》2021年第7期973-977,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医药卫生科技计划项目(2018KY812)。

摘　　要：目的观察前列地尔注射液治疗急性脑梗死的临床效果。方法选取嘉善县第一人民医院2016年8月至2018年8月治疗的急性脑梗死患者300例为观察对象,采用随机数字表法分为对照组和观察组,每组150例。两组均行常规治疗,对照组采用血栓通粉针剂治疗,观察组采用前列地尔注射液治疗。两组疗程均为14 d。比较两组临床效果。结果观察组脑梗死灶体积[(3.16±1.19)cm^(3)]、斑块面积[(0.21±0.05)mm^(2)]、管腔面积[(0.30±0.06)mm^(2)]、颈总动脉内-中膜厚度[(1.05±0.23)mm]、Crouse积分[(2.18±0.61)分]、再通率[98.67%(148/150)]、Barthel指数量表评分[(96.38±1.75)分]、美国国立卫生研究院卒中量表评分[(6.31±1.08)分]、红细胞比容[(41.03±4.28)%]、血浆黏度[(1.12±0.03)mPa/s]均优于对照组[(2.25±1.37)cm^(3)、(0.68±0.46)mm^(2)、(0.89±0.54)mm^(2)、(1.76±0.85)mm、(3.29±0.78)分、72.00%(108/150)、(85.22±1.56)分、(10.18±1.43)分、(50.76±5.31)%、(1.54±0.34)mPa/s],均差异有统计学意义(t=1.869、1.231、1.452、1.326、2.285,χ^(2)=12.528,t=11.428、4.28、17.473、15.071,均P<0.05)。结论在常规治疗基础上,前列地尔注射液治疗急性脑梗死有较好的临床效果。Objective To investigate the clinical efficacy of alprostadil injection in the treatment of acute cerebral infarction.Methods A total of 300 patients with acute cerebral infarction who received treatment in The First People's Hospital of Jiashan,China between August 2016 and August 2018 were included in this study.They were randomly divided into a control group and an observation group(n=150/group).Based on conventional treatment,patients in the control group received Xueshuantong power injection treatment and those in the observation group received alprostadil injection treatment.All patients were treated for 14 days.Clinical efficacy was compared between the control and observation groups.Results In the observation group,infarct volume,plaque area,lumen area,intima-media thickness of the common carotid artery,Crouse score,recanalization rate,Barthel Index,National Institutes of Health Stroke Scale(NIHSS)score,hematocrit and plasma viscosity in the observation group were(3.16±1.19)cm^(3),(0.21±0.05)mm^(2),(0.30±0.06)mm^(2),(1.05±0.23)mm,(2.18±0.61)points,98.67%(148/150),(96.38±1.75)points,(6.31±1.08)points,(41.03±4.28)%,(1.12±0.03)mPa/s,respectively,which were superior to those in the control group[(2.25±1.37)cm^(3),(0.68±0.46)mm^(2),(0.89±0.54)mm^(2),(1.76±0.85)mm,(3.29±0.78)points,72.00%(108/150),(85.22±1.56)points,(10.18±1.43)points,(50.76±5.31)%,(1.54±0.34)mPa/s,t=1.869,1.231,1.452,1.326,2.285,χ^(2)=12.528,t=11.428,4.28,17.473,15.071,all P<0.05].Conclusion Based on conventional treatment,alprostadil injection exhibits good clinical efficacy in the treatment of acute cerebral infarction.

关 键 词：脑梗死 前列地尔 微循环 血液流变学 血细胞比容 预后 临床对照试验 治疗结果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]