EP-BY02型高强度聚焦超声对儿童晚期腹膜后恶性肿瘤的疗效观察  

Efficacy of EP-BY02 high-intensity focused ultrasound in children with advanced retroperitoneal malignancies

作　　者：张延刚[1] 张春燕 ZHANG Yan-gang;ZHANG Chun-yan(Department of Ultrasound,Xi'an Children's Hospital,Xi'an 710003,China;Medical Ultrasound Center,Northwest Women's and Children's Hospital,Xi'an 710003,China)

机构地区：[1]陕西省西安市儿童医院超声科,西安713700 [2]陕西省西北妇女儿童医院医学超声中心,西安713700

出　　处：《中国肿瘤临床与康复》2021年第7期819-822,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨EP-BY02型高强度聚焦超声(HIFU)对儿童晚期腹膜后恶性肿瘤的临床疗效及对胃肠道穿孔的影响。方法选取2014年8月至2019年7月间西安市儿童医院收治的80例儿童晚期腹膜后恶性肿瘤患儿。根据治疗方法不同进行分组,其中采用放射治疗联合HIFU治疗的40例患儿纳入HIFU组,采用放射治疗的40例患儿纳入对照组。记录与随访两组患儿的预后,观察并比较胃肠道穿孔发生情况。结果治疗后,HIFU组的总有效率为82.5%,高于对照组的50.0%,差异有统计学意义(P<0.05)。两组治疗后的疼痛评分低于治疗前,且卡氏评分高于治疗前,HIFU组上述数据优于对照组,差异均有统计学意义(均P<0.05)。两组患儿治疗期间的胃肠道穿孔发生率比较,差异无统计学意义(P>0.05)。HIFU组随访第6个月、9个月与12个月的生存率分别为97.5%、92.5%和80.0%,均高于对照组的82.5%、72.5%和50.0%,差异均有统计学意义(均P<0.05)。结论EP-BY02型HIFU在儿童晚期腹膜后恶性肿瘤中应用,能提高临床疗效和生存率,缓解癌痛,且不会增加胃肠道穿孔发生率。Objective To investigate the clinical efficacy of EP-BY02 high-intensity focused ultrasound(HIFU)in children with advanced retroperitoneal malignancies.Methods From August 2014 to July2019,80 children with advanced retroperitoneal malignancies were selected at Xi’an Children’s Hospital.They were divided into groups based on the therapies they received.Forty chileren receiving radiotherapy plus HIFU were enrolled in the HIFU group and 40 children only receiving radiotherapy were enrolled in the control group.The prognosis of the children were recorded and followed up,and the occurrence of gastrointestinal perforation was observed.Results After the treatment,the overall efficacy rate was 82.5%in the HIFU group,which were higher than 50.0%of the control group(P<0.05).The pain scores were lower in the two groups after the treatment than those before the treatment(all P<0.05),and the Kanofsky scores were higher than those before the treatment(all P<0.05).The above levels were better in the HIFU group than in the control group(all P<0.05).There was no significant difference in the incidence of gastrointestinal perforation between the two groups(P>0.05).The 6-,9-and 12-month survival rates was97.5%,92.5%,and 80.0%,respectively in the HIFU group,which were higher than 82.5%,72.5%,50.0%,respectively of the control group(all P<0.05).Conclusion EP-BY02 high-intensity focused ultrasound can improve clinical efficacy,promote relief of cancer pain and improve survival rate during follow-up without increasing the incidence of gastrointestinal perforation in children with advanced retroperitoneal malignancies.

关 键 词：高强度聚焦超声 儿童 晚期腹膜后恶性肿瘤 癌痛 胃肠道穿孔 生存率 

分 类 号：R735.5[医药卫生—肿瘤]