pH胁迫提高微生物次级代谢产物合成的研究进展  

Recent Progress on the Improvement of Microbial Secondary Metabolite Synthesis by pH Stress

作　　者：王丽[1,2] 陈炎 于超 任喜东 刘新利[1,2] WANG Li;CHEN Yan;YU Chao;REN Xi-dong;LIU Xin-li(State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China;Provincial Key Laboratory of Microbial Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China)

机构地区：[1]齐鲁工业大学(山东省科学院)生物基材料与绿色造纸国家重点实验室,济南250353 [2]齐鲁工业大学(山东省科学院)微生物工程重点实验室,济南250353

出　　处：《齐鲁工业大学学报》2021年第4期20-25,共6页Journal of Qilu University of Technology

基　　金：国家自然科学基金青年科学基金(31701585)。

摘　　要：微生物次级代谢产物正在发挥越来越重要的作用,提升发酵中次级代谢产物产量的研究成为热点。pH胁迫作为一种环境胁迫因子,正在成为一种有效的提高微生物发酵生产能力的策略。本文综述了近年来有关pH胁迫在提高微生物发酵能力的一些研究成果,着重介绍了pH胁迫对微生物发酵中次级代谢产物合成能力的影响,这将有助于今后对微生物发酵生产改进的研究,进一步揭示相关分子机制。这篇综述的另一个目的是将pH胁迫与适应性实验室进化相结合,从基因层次上提高微生物合成次级代谢产物的能力,进一步拓展pH胁迫在微生物发酵和育种方面的应用。microbial secondary metabolites are playing an increasingly important role,researches on the improvement of secondary metabolite production has become a hot spot.As an environmental stress factor,pH stress is becoming an effective strategy to improve the production capacity of microbial fermentation.In this paper,the recent findings were reviewed about the improving effects of pH stress on microbial fermentation capacity,and the influences of secondary metabolite biosynthesis were introduced by pH stress,which will contribute to the future researches on the improvement of microbial fermentation production and further reveal the relevant molecular mechanisms.Another purpose of this review is to combine pH stress with adaptive laboratory evolution to improve the ability of microorganisms to synthesize secondary metabolites at genetic level,and to further expand the application of pH stress in microbial fermentation and breeding.

关 键 词：PH胁迫 菌体活性 次级代谢产物 适应性实验室进化 

分 类 号：TS201.3[轻工技术与工程—食品科学]