Conductance and DNA Translocation Current Blockage of Solid-State Nanopores  

作　　者：LU Bo JIN Wei-Liang ZHAO Qing YU Da-Peng 鲁铂;金伟良;赵清;俞大鹏(State Key Laboratory for Mesoscopic Physics and Electron Microscopy Laboratory,School of Physics,Peking University,Beijing 100871)

机构地区：[1]State Key Laboratory for Mesoscopic Physics and Electron Microscopy Laboratory,School of Physics,Peking University,Beijing 100871

出　　处：《Chinese Physics Letters》2012年第5期244-247,共4页中国物理快报（英文版）

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 50902004 and 11023003;the National Basic Research Program of China under Grant Nos 2009CB623703 and 2011CB707601;the International Science&Technology Cooperation Program of China Sino Swiss Science and Technology Cooperation Program(2010DFA01810).

摘　　要：The current blockage during DNA molecule translocation through a solid-state nanopore is very important in DNA analysis techniques based on nanopores.We use Poisson-Nernst-Planck descriptions of electrolyte behavior in a nanopore with and without the presence of DNA molecules to simulate the nanopore conductance and current blockage of DNA molecules. Actual experimental parameters,such as pore size,length of nanopores,DNA drift velocity,and the charge issue of nanopores and DNA,are applied to evaluate the precise current blockage amplitude,which is found to agree very well with the experimental results.

关 键 词：pores PRECISE ELECTROLYTE 

分 类 号：R73[医药卫生—肿瘤]