产前超声提示孤立性透明隔腔宽度异常的临床意义  

Clinical Significance of Prenatal Ultrasound in Diagnosing with Solitary Abnormal Width of Cavum Septum Pellucidum

作　　者：李洁[1] 王晨静 李涵 常明兰 栗河舟[1] 张华[2] 朱功升[3] LI Jie;WANG Chenjing;LI Han;CHANG Minglan;LI Hezhou;ZHANG Hua;ZHU Gongsheng(Department of Ultrasound,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;不详)

机构地区：[1]郑州大学第三附属医院超声科,河南郑州450052 [2]郑州大学第三附属医院产前诊断中心,河南郑州450052 [3]郑州大学第三附属医院放射科,河南郑州450052

出　　处：《中国医学影像学杂志》2021年第7期726-729,737,共5页Chinese Journal of Medical Imaging

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20190377)。

摘　　要：目的分析产前超声提示胎儿孤立性透明隔腔宽度异常的产前诊断及胎儿预后,探讨其临床意义。资料与方法回顾性选取行产前系统超声筛查的270例孤立性透明隔腔异常胎儿,分为增宽组30例、未显示组33例、狭小组207例,比较各组孕妇年龄、胎儿检出孕周、影像检查结果、羊水穿刺结果、临床预后等。结果染色体检查:增宽组2例异常,狭小组1例染色体2q13区段检出489 k缺失片段;MRI检查补充诊断增宽组1例超声漏诊的胼胝体部分缺失,发现未显示组11例存在狭小的透明隔腔;有效随访222例活产儿至2~29个月,生长发育与同龄儿相比未见明显异常;增宽组超声检出孕周较其他两组晚(P<0.05),3组孕妇年龄差异无统计学意义(P>0.05)。结论胎儿颅脑MRI及羊水穿刺检查在超声提示孤立性透明隔腔异常胎儿中有一定的应用价值,有助于指导临床决策,孤立性透明隔腔宽度异常胎儿近期预后良好。Purpose To analyze the prenatal diagnosis and fetal outcome of fetal solitary abnormal width of cavum septum pellucidum(CSP)diagnosed by prenatal ultrasound,and to explore its clinical significance.Materials and Methods A total of 270 fetuses with solitary abnormal width of CSP who were screened by prenatal ultrasound were divided into widened group(n=30),unshown group(n=33)and narrow group(n=207).The age of pregnant women,gestational age of fetus,results of images and gene,and clinical prognosis were all statistically analyzed.Results For the chromosomal examination,two cases were chromosomal abnormalities in the broadened group,one case in the narrow group had 489 k deletions in the 2 q13 segment.One case of partial agenesis of the corpus callosum missed by ultrasound was supplementally diagnosed in the broadened group via MRI examination,and 11 cases with the narrow pellucid septum were also detected in the non-visualisation group.A total of 222 live births were followed up to 2-29 months,and there were no significantly differences in growth and development between the age-matched control infants and infants with fetal solitary abnormal width of CSP.The gestational week of the widened group was detected significantly later by ultrasound than that of the other two groups(P<0.05),and there were no significant differences in maternal ages among the three groups(P>0.05).Conclusion Fetal craniocerebral MRI and amniocentesis have certain application value in fetuses with abnormal isolated pellucid septum by ultrasound,guiding the clinical decision-making.The fetus with isolated abnormal width of CSP has a good short-term prognosis.

关 键 词：先天畸形 孤立性透明隔腔宽度异常 超声检查 产前 磁共振成像 胎儿 

分 类 号：R445.4[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]