肠道微生态在食物过敏发生及防治中的作用  

Role of intestinal microecology in the occurrence and prevention of food allergies

作　　者：余熠[1] 苏雯[1] 张清清[1] 陈岩岩 许春娣[1] YU Yi;SU Wen;ZHANG Qingqing;CHEN Yanyan;XU Chundi(Department of pediatrics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院儿内科,上海200025

出　　处：《临床儿科杂志》2021年第8期636-640,共5页Journal of Clinical Pediatrics

摘　　要：儿童食物过敏(FA)是过敏进程的主要早期表现。生命早期的环境和饮食因素可以通过影响肠道微生态,改变肠屏障功能和肠道免疫表型,参与FA的发生及其相关疾病的发展。微生态疗法有望在一定程度上防治FA和其他过敏性疾病,但仍需要更多研究验证某些特定益生菌、益生元等对防治FA的有效性、安全性。Food allergy in children is a major early manifestation of the atopic march.Environmental and dietary factors in early life can be involved in the development of food allergy and its related diseases by affecting the intestinal microecology,altering intestinal barrier function and intestinal immunophenotype.Microecological therapy is expected to prevent and treat food allergy and other allergic diseases to some extent.More studies are still needed to verify the efficacy and safety of certain specific prebiotics and/or probiotic in the prevention and treatment of food allergy.

关 键 词：食物过敏 特应性进程 肠道微生态 免疫耐受 益生菌 益生元 

分 类 号：R725.9[医药卫生—儿科]