8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物的合成与表征  

Synthesis and Characterization of 8-(3-Chlorophenyl)-3-methylthio-1-phenyl-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4-one derivatives

作　　者：宋崇虎 朱咏梅[1] 陈朴青[1] 罗劲[1] SONG Chong-hu;ZHU Yong-mei;CHEN Pu-qing;LUO Jin(Analytical and Testing Center,Jiangxi Normal University,Jiangxi 330022,China)

机构地区：[1]江西师范大学分析测试中心,江西南昌330022

出　　处：《精细化工中间体》2021年第3期30-32,41,共4页Fine Chemical Intermediates

基　　金：江西师范大学青年英才项目。

摘　　要：以吡唑膦亚胺、3-氯苯基异氰酸酯和取代苯氧乙(丙)酰肼为原料,通过串联氮杂Wittig关环反应合成了6个未见文献报道的化合物8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物(■),通过核磁共振氢碳谱和HRMS等确证进行了表征。Six novel 8-(3-chlorophenyl)-3-methylthio-1-phenyl-pyrazolo[3,4-d][1,2,4]triazolo[1,5-a]pyrimidin-4-one derivatives(■)were synthesized via tandem Aza-Wittig and annulation reactions of the iminophosphorane,3-chlorophenyl isocyanate,and substituted 2-phenoxy acetohydrazide(or 2-phenoxypropanehydrazide).Their structures were confirmed by 1H NMR,13C NMR,and HRMS.

关 键 词：膦亚胺 氮杂WITTIG反应 合成 吡唑并[3 4-d][1 2 4]三唑并[1 5-a]嘧啶-4-酮衍生物 

分 类 号：O626.4[理学—有机化学]