上海市嘉定区炎症性肠病患者的粪便钙卫蛋白检测研究  

Study of fecal calprotectin detection in patients with inflammatory bowel disease in Jiading district of Shanghai of China

作　　者：杨翠萍 全旭 孙顺昌[1] 张梦茵[1] 张金叶 贾颖 俞骁珺[1] 谢玲[1] 蔡波尔 吴云林[1] 陈平[1] Yang Cuiping;Quan Xu;Sun Shunchang;Zhang Mengyin;Zhang Jinye;Jia Ying;Yu Xiaojun;Xie Ling;Cai Bo′er;Wu Yunlin;Chen Ping(Department of Gastroenterology,Ruijin Hospital of School of Medicine of Shanghai Jiaotong University,Shanghai 201801,China)

机构地区：[1]上海交通大学医学院附属瑞金医院消化内科,201801

出　　处：《中华消化病与影像杂志（电子版）》2021年第5期193-195,共3页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的探讨粪便钙卫蛋白(FC)在上海市嘉定地区炎症性肠病患者临床诊断中的意义。方法选取2020年3月至2020年5月上海瑞金医院北部院区43例研究对象的粪便样本,分成2组,炎症性肠病(IBD)组28例和健康对照组15例。采用荧光免疫层析法定量检测粪便中FC浓度。结果15例健康者FC浓度为(40.63)μg/g,28例IBD患者平均为(323.45)μg/g。IBD患者与健康者FC浓度比较有显著差别(P<0.05)。以60μg/g为临界值时,FC判断IBD是否活动的灵敏度和特异度分别为82.14%和86.67%,活动期IBD患者与静止期IBD患者和健康者FC浓度比较均也有显著差异(P<0.05)。结论FC检测作为一种非侵入性诊疗方法,可作为内镜下诊断疾病活动性的一种替代指标,在上海嘉定地区诊断IBD以及评估疾病活动性具有良好的应用价值。Objective To investigate the value of fecal calprotectin(FC)in the diagnosis of patients with inflammatory bowel disease(IBD)in Jiading district of Shanghai of China.Methods The fecal samples of 43 subjects from March 2020 to May 2020 in North District of Shanghai Ruijin Hospital were collected and divided into two groups:IBD group(n=28)and healthy control group(n=15).Fluorescence immunochromatography was used to quantitatively detect FC concentration in feces.Results The FC concentration in 15 healthy subjects was 40.63μg/g,and that in 28 patients with was 323.45μg/g.There was a significant difference in FC concentration between IBD group and control group(P<0.05).When 60μg/g was taken as the critical value,the sensitivity and specificity of FC to determine whether IBD was active or not were 82.14%and 86.67%,respectively.There were also significant differences in FC concentrations between active IBD patients and inactive IBD patients and healthy subjects(P<0.05).Conclusion FC test,as a non-invasive diagnosis and treatment method,can be used as an alternative index for endoscopic diagnosis of disease activity,which has a good application value in the diagnosis of IBD and the assessment of disease activity in Jiading district of Shanghai of China.

关 键 词：粪钙卫蛋白 炎症性肠病 疾病活动度 溃疡性结肠炎 克罗恩病 

分 类 号：R574[医药卫生—消化系统]