生物信息学分析包膜与非包膜病毒的受体蛋白差异  

Systematic Comparison of the Protein Receptors used by Enveloped and Non⁃enveloped Viruses in Mammals

作　　者：喻芬 张征 彭友松 YU Fen;ZHANG Zheng;PENG Yousong(College of Biology,Hunan University,Changsha 410000,China)

机构地区：[1]湖南大学生物学院,长沙410000

出　　处：《病毒学报》2021年第4期894-899,共6页Chinese Journal of Virology

基　　金：国家重点研发计划(项目号:2016YFD0500301),题目:重大人兽共患病疫情的快速鉴定、溯源预警及阻断策略研究;湖南省自然科学基金(项目号:2020JJ3006),题目:病毒性传染病的生物信息化研究。

摘　　要：病毒与受体相互作用对于病毒感染宿主细胞至关重要。为了深入理解病毒对于受体蛋白的选择机制,本研究从结构、功能、宿主蛋白相互作用网络以及组织表达量等四个方面系统性地分析和比较了哺乳动物中包膜与非包膜病毒的受体蛋白差异。结果表明,包膜病毒和非包膜病毒的受体蛋白具有相似的结构域组成和功能,但是非包膜病毒的受体蛋白相对于包膜病毒具有更多的结构域数目、更高的N-糖基化水平、在宿主蛋白相互作用网络中有更高的连接度和节点介数、以及在宿主中有更高的表达。本研究有助于加深我们对于哺乳动物中包膜与非包膜病毒受体选择机制的理解,同时也对病毒受体的鉴定具有一定的参考价值。Virus⁃receptor interaction is essential for the viral infection of host cells.This study systematically analyzed the structure,function,protein⁃protein interaction and expression of protein receptors used by enveloped and non⁃enveloped viruses in mammals.We found that the protein receptors used by enveloped and non⁃enveloped viruses had similar composition of protein domains and similar molecular functions,but the protein receptors used by the non⁃enveloped viruses had had more protein domains,higher level of N⁃glycosylation,larger node degrees and betweennesses in the host protein⁃protein interaction network(PPIN)and higher expressions in common human tissues,than those of enveloped viruses.This study could deepen our understanding of virus⁃receptor interaction in the enveloped and non⁃enveloped viruses,and facilitates the development of effective methods for viral receptor identification.

关 键 词：哺乳动物病毒 病毒受体 生物信息学 计算生物学 包膜病毒 

分 类 号：Q939.4[生物学—微生物学]