注射用甘氨双唑钠对老年局部晚期宫颈癌患者的疗效  

Effect of Sodium Glycididazole for Injection on Elderly Patients with Locally Advanced Cervical Cancer

作　　者：王莹莹 WANG Yingying(Department of Radiology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院放射科,河南郑州450014

出　　处：《河南医学研究》2021年第19期3575-3577,共3页Henan Medical Research

摘　　要：目的探讨注射用甘氨双唑钠对老年局部晚期宫颈癌患者的疗效。方法选取郑州大学第二附属医院2018年1月至2020年1月收治的160例老年局部晚期宫颈癌患者,按照治疗方案分为两组,各80例。放疗组接受三维适形外照射联合后装腔内放疗,研究组在放疗组基础上联合注射用甘氨双唑钠治疗。比较两组近期疗效、疗效达完全缓解(CR)、部分缓解(PR)时所需照射量、不良反应发生情况及治疗前后生活质量[生命质量核心量表(QOL-C30)评分]。结果研究组疾病控制率[96.25%(77/80)]较放疗组[83.75%(67/80)]高(P<0.05);研究组疗效达到CR、PR时所需照射量低于放疗组(P<0.05);研究组不良反应发生率[61.25%(49/80)]与放疗组[67.50%(54/80)]比较,差异无统计学意义(P>0.05);治疗后研究组QOL-C30评分低于放疗组(P<0.05)。结论注射用甘氨双唑钠安全性较高,不仅能提高老年局部晚期宫颈癌患者近期疗效及放射增敏效果,且能改善患者生活质量。Objective To investigate the effect of sodium glycididazole for injection on elderly patients with locally advanced cervical cancer.Methods total of 160 elderly patients with locally advanced cervical cancer from January 2018 to January 2020 in the Second Affiliated Hospital of Zhengzhou University were selected and divided into two groups according to the treatment plan,with 80 cases in each group.Radiotherapy group received three-dimensional conformal external irradiation combined with post-loading intracavitary radiotherapy,and experimental group was treated with injection of sodium glycididazole on the basis of radiotherapy group.The short-term curative effect,amount of radiation required to achieve complete response(CR)and partial response(PR),occurrence of adverse reactions and quality of life[quality of life questionnare-core 30(QOL-C30)]before and after treatment were compared between the two groups.Results The disease control rate[96.25%(77/80)]of experimental group was higher than that[83.75%(67/80)]of radiotherapy group(P<0.05).The radiation doses required for experimental group to reach CR and PR were lower than those of radiotherapy group(P<0.05).The adverse reaction rate of experimental group was 61.25%(49/80),and the adverse reaction rate of radiotherapy group was 67.50%(54/80).There was no statistical difference in the adverse reaction rate between the two groups(P>0.05).After treatment,the QOL-C30 score of experimental group was lower than that of radiotherapy group(P<0.05).Conclusion Sodium glydidazole for injection is safer.It can not only improve the short-term curative effect and radiosensitization effect of elderly patients with locally advanced cervical cancer,but also improve the quality of life of patients.

关 键 词：老年人 局部晚期宫颈癌 注射用甘氨双唑钠 放射增敏作用 不良反应 

分 类 号：R737.3[医药卫生—肿瘤]