丹参注射液联合奥曲肽对重症急性胰腺炎的疗效及其对凝血功能、血液流变学的影响  

Effect of Danshen Injection combined with octreotide on coagulation function and hemorheology in patients with severe acute pancreatitis

作　　者：相兵 XIANG Bing(Department of Gastroenterology,Guannan County People's Hospital,Lianyungang,222500,China)

机构地区：[1]灌南县人民医院消化内科,江苏连云港222500

出　　处：《中国处方药》2021年第8期137-139,共3页Journal of China Prescription Drug

摘　　要：目的探究丹参注射液联合奥曲肽对重症急性胰腺炎(SAP)疗效及其对凝血功能、血液流变学的影响。方法选择80例SAP患者,分成观察组及对照组,各40例。对照组采取奥曲肽治疗,观察组在此基础上联合丹参注射液治疗。观察两组患者的疗效、凝血功能和血液流变学特征。结果与对照组相比,观察组疗效明显更高,差异具有统计学意义(χ^(2)=12.052,P<0.05)。与治疗前相比,观察组治疗10 d后的高切全血黏度、低切全血黏度、红细胞压积、血小板粘附率、血浆黏度明显更低,差异具有统计学意义(t=7.449、9.404、7.093、8.043、9.048,P<0.05),观察组治疗10 d后的高切全血黏度、低切全血黏度、红细胞压积、血小板粘附率、血浆黏度较对照组治疗10 d后明显更低,差异具有统计学意义(t=9.653、9.042、8.485、8.135、9.982,P<0.05),与治疗前相比,观察组和对照组治疗后的APTT和PT明显更高,PLT和FIB水平明显更低,差异具有统计学意义(P<0.05)。与对照组相比,观察组治疗后APTT和PT明显更高,PLT和FIB水平明显更低,差异具有统计学意义(P<0.05)。结论丹参注射液联合奥曲肽可有效提高SAP患者疗效,并改善凝血功能、血液流变学情况。Objective To observe the effect of SAP patients treated with Danshen Injection combined with octreotide.Methods 80 SAP patients were selected and divided into observation group and control group,40 cases in each group.The control group was treated with octreotide,and the observation group was treated with Danshen Injection on this basis.The curative effect,coagulation function and hemorheological characteristics of the two groups of patients were observed.Results Compared with the control group,the curative effect of the observation group was significantly higher,and the difference was statistically significant(χ^(2)=12.052,P<0.05).Compared with before treatment,the high shear whole blood viscosity,low shear whole blood viscosity,hematocrit,platelet adhesion rate and plasma viscosity of the observation group after 10 days of treatment were significantly lower(t=7.449,9.404,7.093,8.043,9.048,P<0.05).After 10 days of treatment,the levels of APTT,PT and FIB were significantly higher than those before treatment(t=9.653,9.042,8.485,8.135,9.982,P<0.05).Compared with the control group,the levels of APTT,PT and FIB in the observation group were significantly higher after treatment,and PLT was significantly lower(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=1.421,P>0.05)Conclusion The continuous intervention mode based on the network platform can improve the cognitive level of patients with coronary heart disease,improve the postoperative quality of patients,and have fewer adverse reactions.

关 键 词：丹参注射液 奥曲肽 重症急性胰腺炎 凝血功能 血液流变学特征 

分 类 号：R576[医药卫生—消化系统]