不同发病状态溃疡性结肠炎患者肠道菌群变化及优势菌敏感性抗菌药物分析  

Changes of Intestinal Flora and Pharmaceutical Analysis of Antimicrobial Susceptibility of Dominant Bacteria in Patients with Ulcerative Colitis in Different Disease Onset State

作　　者：王典[1] WANG Dian(Dept.of Infectious Diseases,the People's Hospital of Tanghe County,Nanyang,Henan 473400)

机构地区：[1]南阳市唐河县人民医院感染性疾病科,河南南阳473400

出　　处：《中国肛肠病杂志》2021年第5期44-46,共3页Chinese Journal of Coloproctology

摘　　要：为探讨不同发病状态溃疡性结肠炎(UC)患者肠道菌群变化、优势菌敏感性抗菌药物,选择2019年6月至2020年6月我院收治的84例UC患者为研究对象,根据发病状态分为急性发作组(30例)、慢性复发组(26例)、慢性持续组(28例),并选择同期健康体检者30人作为对照组。采集4组受试者新鲜粪便,计数大肠埃希菌(E)、双歧杆菌(B),计算大肠埃希菌/双歧杆菌(E/B)比值,分析优势细菌(可能感染的细菌),并对其进行药敏试验。对比分析结果显示,急性发作组、慢性复发组、慢性持续组、对照组粪便B数量依次增多,E数量依次减少,E/B比值依次减小,组间比较差异均有统计学意义(P<0.05)。急性发作组细菌(优势菌)感染率高于慢性复发组和慢性持续组(P<0.05),慢性复发组与慢性持续组比较差异无统计学意义(P>0.05)。UC患者粪便培养优势细菌以E和金黄色葡萄球菌为主,进一步药敏试验发现,这两种菌对万古霉素、哌拉西林-舒巴坦的敏感率为100%。结果表明,不同发病状态UC患者肠道菌群分布、优势菌敏感性抗菌药物有所不同,急性发作期UC肠道菌群紊乱最为显著,优势细菌感染率最高。In order to investigate the changes of intestinal flora and analyze antimicrobial susceptibility of dominant bacteria in patients with ulcerative colitis(UC)in different disease onset states,84 patients with UC admitted to author’s hospital from June 2019 to June 2020 were selected as the research objects.According to the onset status,they were divided into acute attack group(30 cases),chronic recurrence group(26 cases)and chronic persistent group(28 cases),and 30 healthy examinees at the same period were selected as the control group.Fresh feces of the four groups were collected,Ec.oli(E)and Bifidobacterium(B)were counted,Ec.oli/Bifidobacterium(E/B)ratio was calculated,dominant bacteria(possibly infected bacteria)were analyzed,and drug sensitivity test was carried out.As results of comparative analysis,the number of fecal B in acute attack group,chronic recurrence group,chronic persistent group and control group increased in turn,the number of fecal E decreased in turn,and the E/B ratio decreased in turn.The differences between the groups were statistically significant(P<0.05).The bacterial infection rate of acute attack group was higher than that of chronic recurrence group and chronic persistent group(P<0.05).There was no significant difference between chronic recurrence group and chronic persistent group(P>0.05).The dominant bacteria in fecal culture of UC patients were mainly Staphylococcus aureus and E.aureus.Further drug sensitivity test showed that the sensitivity rate of these two bacteria to vancomycin and piperacillin sulbactam was 100%.The results show that the distribution of intestinal microflora and the sensitivity of dominant bacteria to antibiotics are different in patients with UC in different disease states.The most significant disturbance of intestinal microflora and the highest infection rate of dominant bacteria are found in patients with UC in acute attack stage.

关 键 词：溃疡性结肠炎 发病状态 肠道菌群 药敏试验 分析 

分 类 号：R574.62[医药卫生—消化系统]