肿瘤细胞中m^(6)A功能的研究  

The study of m^(6)A functions in tumor cells

作　　者：柏小青 孟祥宁[1,2] Bai Xiaoqing;Meng Xiangning(Laboratory of Medical Genetics,Harbin Medical University,Harbin 150081,China;Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China(Harbin Medical University),Ministry of Education,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081 [2]中国遗传资源保护与疾病防控教育部重点实验室(哈尔滨医科大学),150081

出　　处：《国际遗传学杂志》2021年第3期162-167,共6页International Journal of Genetics

基　　金：教育部长江学者和创新团队发展计划(IRT1230)。

摘　　要：m^(6)A修饰是真核生物中最常见、最丰富的修饰形式之一,在不改变碱基序列的情况下对基因的转录后表达水平发挥调控作用。该修饰过程是动态可逆的,由甲基转移酶、去甲基化酶和相应的读取蛋白协同调控,参与m^(6)A修饰的酶出现异常会导致肿瘤等一系列疾病的发生。本文综述了m^(6)A修饰相关蛋白的组成与功能,以及m^(6)A修饰在肿瘤增殖、侵袭与转移、血管生成、炎症反应、免疫反应、基因组不稳定、细胞代谢中的功能和调节机制。N6-methyladenosine(m^(6)A)modification is one of the most common and abundant modification form in eukaryotes,and it can regulate the post-transcriptional expression levels of genes without changing the base sequences.The modification process is dynamic and reversible and is coordinately regulated by methyltransferases,demethylases and corresponding reader proteins.Abnormality of enzymes for m^(6)A modificationcan cause a series of diseases,such as tumors.This article reviews the composition and functions of m^(6)A modification-related proteins,and the functions and regulatory mechanisms of m^(6)A modification in the processes of tumor proliferation,invasion and metastasis,angiogenesis,inflammatory response,immune response,genomic instability,and cell metabolism.

关 键 词：m^(6)A 甲基转移酶 去甲基化酶 读取蛋白 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]