Screening for volatile sulphur compounds in a fatal accident case  

作　　者：Ping Xiang Huosheng Qiang Baohua Shen Min Shen 

机构地区：[1]Department of Forensic Toxicology,Shanghai Key Laboratory of Forensic Medicine,Shanghai Forensic Service Platform,Institute of Forensic Science,Ministry of Justice,PRC,Shanghai,China [2]Pharmacy School of Wenzhou Medical University,Wenzhou,China

出　　处：《Forensic Sciences Research》2017年第4期192-197,共6页法庭科学研究（英文）

基　　金：supported by the National,Shanghai Scientific Program;Technology Committee of Shanghai Municipality for their financial support[grant number 2016YFC0800704/15DZ1207500/14DZ2270800/16DZ2290900]of this study.

摘　　要：Acute fatal poisoning due to the inhalation of toxic gas frequently occurs in China.Volatile sulphur compounds(VSCs)are toxic to humans.In fatal poisoning investigations,such as those in industrial settings,a number of VSCs,including methanethiol(MT),dimethyl sulphide(DMS),dimethyl disulphide(DMDS)and dimethyl trisulphide(DMTS),can coexist.To date,there is limited data regarding these compounds in post-mortem cases.In the present study,we report toxicological findings in a fatal accident case with two victims.Headspace gas chromatography/flame ionization detector with two columns of different polarities was utilized to screen MT,DMS,DMDS and DMTS in blood.The limits of detection in both methods were 0.05 mg/mL.No sulphur compounds were detected in the blood samples of the two victims.DMS and DMDS were detected in the lungs at concentrations of 0.5 and 1.3 mg/g and 2.2 and 4.1 mg/g,respectively.DMDS liver concentrations were 2.5 and 6.5 mg/g.In addition to hydrogen sulphide,screening for additional VSCs could help establish the cause of death.

关 键 词：Forensic science forensic toxicology volatile sulphur compounds HS-GC/FID SCREENING fatal accident case 

分 类 号：R78[医药卫生—口腔医学]