LIPC基因rs10468017多态性与年龄相关性黄斑变性易感性关系的Meta分析  

Association between LIPC gene rs10468017 polymorphism and the susceptibility to age-related macular degeneration:a Meta-analysis

作　　者：顾虹 徐张幸 沈肇萌[1,2] 李志国 Gu Hong;Xu Zhangxing;Shen Zhaomeng;Li Zhiguo(Ningbo Medical Center Li Huili Hospital,Ningbo 315040,China;Ningbo Eye Hospital,Ningbo 315040,China)

机构地区：[1]宁波市医疗中心李惠利医院,315040 [2]宁波市眼科医院,315040

出　　处：《中华实验眼科杂志》2021年第8期729-736,共8页Chinese Journal Of Experimental Ophthalmology

基　　金：宁波市自然科学基金项目(2018A610364)。

摘　　要：目的系统评价人类肝脂肪酶(LIPC)基因rs10468017多态性与年龄相关性黄斑变性(AMD)易感性的关系。方法计算机检索英文数据库(PubMed、Embase、EBSCO、Web of Knowledge、Cochrane图书馆)及中文数据库(中国知网、万方数据、维普、中国生物医学文献数据库)自建库起至2019年12月31日关于LIPC基因rs10468017多态性位点与AMD研究的文献。采用Stata 12.0软件计算等位基因模型(T和C)、杂合子模型(TC和CC)及纯合子模型(TT和CC)3种遗传模型下该多点性位点和AMD相关性的比值比(OR值)及95%置信区间(CI),并进一步按AMD类型和种族进行亚组分析,分别计算OR值及95%CI,进行Meta分析。结果本研究共纳入21篇文献,包括AMD患者25649例和正常对照人群26294例。Meta分析结果显示,rs10468017多态性的T等位基因与AMD发生风险显著相关(T vs.C:OR=0.83,95%CI:0.80~0.87;TC vs.CC:OR=0.82,95%CI:0.75~0.90;TT vs.CC:OR=0.65,95%CI:0.56~0.76)。亚组分析结果显示,rs10468017多态性与早期AMD(OR=0.87,95%CI:0.78~0.96)、晚期AMD(OR=0.83,95%CI:0.77~0.88)、地图样萎缩(OR=0.79,95%CI:0.72~0.87)及脉络膜新生血管(OR=0.83,95%CI:0.78~0.89)均相关。进一步对种族进行分层分析显示,高加索人群中T等位基因与AMD相关(早期AMD:OR=0.77,95%CI:0.67~0.89;晚期AMD:OR=0.80,95%CI:0.75~0.87),亚洲人群中T等位基因与AMD无显著相关性(早期AMD:OR=0.98,95%CI:0.85~1.13;晚期AMD:OR=0.93,95%CI:0.81~1.06)。结论rs10468017多态性的T等位基因与AMD显著相关,可降低AMD的发生风险,虽然这种相关性存在于AMD的各个表型中,但是存在一定的种族差异。Objective To systematically evaluate the association between the hepatic lipase(LIPC)gene rs10468017 polymorphism and susceptibility to age-related macular degeneration(AMD).Methods A systematic search was performed in both English databases(PubMed,Embase,EBSCO,Web of Knowledge and Cochrane library)and Chinese databases(CNKI,WanFang,VIP and CBM)from database establishment to December 31,2019.Literature about LIPC rs10468017 polymorphism and AMD was searched.Odds ratios(OR)and 95%confidence intervals(CI)of allele mode(T and C),heterozygous model(TC and CC)and homozygous model(TT and CC)as well as the correlation between types of AMD and races were calculated using Stata 12.0 software.Results Twenty-one studies were included in the Meta-analysis.There were 25649 AMD patients and 26294 normal controls.There was a significant correlation between LIPC rs10468017 polymorphism and risk of AMD in different genetic models(T vs.C:OR=0.83,95%CI:0.80-0.87;TC vs.CC:OR=0.82,95%CI:0.75-0.90;TT vs.CC:OR=0.65,95%CI:0.56-0.76).The subgroup analysis showed that the LIPC rs10468017 polymorphism was significantly associated with the risk of early AMD(OR=0.87,95%CI:0.78-0.96),advanced AMD(OR=0.83,95%CI:0.77-0.88),geographic atrophy(OR=0.79,95%CI:0.72-0.87)and choroidal neovascularization(OR=0.83,95%CI:0.78-0.89).Stratified analysis by ethnicity showed that there was a significant association between T allele and the decreased risk of AMD in the Caucasian population(early AMD:OR=0.77,95%CI:0.67-0.89;advanced AMD:OR=0.80,95%CI:0.75-0.87),but not in the Asian population(early AMD:OR=0.98,95%CI:0.85-1.13;advanced AMD:OR=0.93,95%CI:0.81-1.06).Conclusions There is a significant association between T allele of LIPC rs10468017 polymorphism and the reduced risk of AMD,which exists in different subtypes of AMD with certain racial differences.

关 键 词：年龄相关性黄斑变性 人类肝脂肪酶基因 单核苷酸多态性 META分析 

分 类 号：R774.5[医药卫生—眼科]