胆囊癌组织星形胶质细胞上调基因1异常表达与临床病理及预后的关系  

The relationship between abnormal expression of astrocytes up-regulated gene 1 in gallbladder cancer tissue and clinicopathology and prognosis

作　　者：崔大鹏[1] 张迎春[2] 宋文丽[3] 张鹏娟[3] 张星月 刘振显[2] 连晶晶[4] 刘博[5] CUI Dapeng;ZHANG Yingchun;SONG Wenli;ZHANG Pengjuan;ZHANG Xingyue;LIU Zhenxian;LIAN Jingjing;LIU Bo(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China;不详)

机构地区：[1]河北北方学院附属第一医院肝胆外科,河北张家口075000 [2]河北北方学院附属第一医院普通外科,河北张家口075000 [3]河北北方学院附属第一医院护理部,河北张家口075000 [4]河北北方学院附属第一医院检验科,河北张家口075000 [5]河北北方学院附属第一医院病理科,河北张家口075000

出　　处：《实用医学杂志》2021年第15期1963-1966,共4页The Journal of Practical Medicine

基　　金：2019年度河北省医学科学研究课题计划(编号:20190915)。

摘　　要：目的探讨胆囊癌组织星形胶质细胞上调基因1(AEG-1)表达与临床病理及预后的关系。方法选取2016年1月至2018年6月收治的128例胆囊癌患者,均于术后进行癌组织AEG-1检测。随访2年,记录生存时间。采用多因素COX回归分析胆囊癌患者预后影响因素,绘制Kaplan-Meier生存曲线。结果128例患者癌组织AEG-1阳性率71.87%。手术方式、肿瘤最大径、分化程度、TNM分期、胆总管浸润、淋巴结转移、AEG-1表达是生存影响因素(P<0.05)。AEG-1阳性和阴性患者生存情况差异有统计学意义(P=0.009)。结论胆囊癌组织AEG-1表达与肿瘤最大径、病理分型、分化程度、TNM分期、周围组织侵犯等有关,且AEG-1表达是预后影响因素。Objective To investigate the relationship between the expression of astrocyte elevated gene-1(AEG-1)in gallbladder cancer tissue and clinicopathology and prognosis.Methods A total of 128 patients with gallbladder cancer admitted from January 2016 to June 2018 were selected to take AEG-1 detection of cancer tissues after surgery.The survival time was recorded during a 2-year follow up.Multivariate COX regression was used to analyze the prognostic factors of patients with gallbladder cancer,while Kaplan-Meier survival curve was drawn.Results The positive rate of AEG-1 in cancer tissues of 128 patients was 71.87%.Surgical method,maximum tumor diameter,degree of differentiation,TNM staging,common bile duct infiltration,lymph node metastasis and AEG-1 expression were the survival factors(P<0.05).There was statistically significant difference in survival between AEG-1 positive and negative patients(P=0.009).Conclusion The expression of AEG-1 in gallbladder cancer tissue is related to the maximum diameter of the tumor,pathological type,degree of differentiation,TNM stage,surrounding tissue invasion,etc.,and the expression of AEG-1 is a prognostic factor.

关 键 词：胆囊癌 星形胶质细胞上调基因1 临床病理 预后 生存分析 血管新生 细胞凋亡 

分 类 号：R735.8[医药卫生—肿瘤]