乳腺癌患者HFUS图像与Ki-67、Her-2、PR、ER表达的相关性  

Correlation between HFUS features and the expression of Ki-67,HER-2,proto oncogene,and estrogen receptor in patients with breast cancer

作　　者：张宝方 黄穗 李少英[3] 夏勇[4] 陈瑞瑞 林小影[1] ZHANG Bao-fang;HUANG Sui;LI Shao-ying;XIA Yong;CHEN Rui-rui;LIN Xiao-ying(Department of Ultrasound Medicine,Shenzhen Bao'an Womens and Children's Hospital,Shenzhen 518101,Guangdong,CHINA;Department of Pathology,Shenzhen Bao'an Womens and Children's Hospital,Shenzhen 518101,Guangdong,CHINA;Department of Mastidaceae,Shenzhen Bao'an Womens and Children's Hospital,Shenzhen 518101,Guangdong,CHINA;Central Laboratory,Shenzhen Bao'an Womens and Children's Hospital,Shenzhen 518101,Guangdong,CHINA;Department of Health,Shenzhen Bao'an Womens and Children's Hospital,Shenzhen 518101,Guangdong,CHINA)

机构地区：[1]深圳市宝安区妇幼保健院超声医学科,广东深圳518101 [2]深圳市宝安区妇幼保健院病理科,广东深圳518101 [3]深圳市宝安区妇幼保健院乳甲科,广东深圳518101 [4]深圳市宝安区妇幼保健院中心实验室,广东深圳518101 [5]深圳市宝安区妇幼保健院保健部,广东深圳518101

出　　处：《海南医学》2021年第15期1934-1938,共5页Hainan Medical Journal

基　　金：广东省深圳市宝安区医疗卫生基础研究项目(编号:2019JD391)。

摘　　要：目的探讨乳腺癌患者高频超声(HFUS)图像与增殖细胞核抗原(Ki-67)、原癌基因(Her-2)、孕激素受体(PR)、雌激素受体(ER)表达的相关性。方法回顾性分析深圳市宝安区妇幼保健院2017年10月至2020年12月接诊的110例乳腺癌患者临床资料,记录所有患者HFUS图像表现及Ki-67、Her-2、PR、ER阳性率表达情况,采用Spearman相关性分析HFUS图像和Ki-67、Her-2、PR、ER的相关性。结果乳腺癌组织中Ki-67的阳性率为67.27%(74/110),Her-2的阳性率为28.18%(31/110),PR的阳性率为50.91%(56/110),ER的阳性率为67.27%(74/110);Ki-67在肿块大小≥2 cm、无微钙化及无毛刺征中的阳性率分别为77.19%、77.19%、80.00%,明显高于肿块大小<2 cm、有微钙化及毛刺征的56.60%、56.60%、56.67%,差异均有统计学意义(P<0.05);Her-2在肿块大小≥2 cm、血流分级Ⅱ~Ⅲ级、有淋巴结转移中的阳性率分别为38.60%、36.51%、40.00%,明显高于肿块大小<2 cm、血流分级0~1级、无淋巴结转移的16.98%、17.02%、16.36%,差异均有统计学意义(P<0.05);PR在肿块大小<2 cm、后方回声有衰减中的阳性率分别为62.26%、73.08%,明显高于肿块大小≥2 cm、后方回声无衰减的40.35%、44.05%,差异均有统计学意义(P<0.05);ER在肿块大小<2 cm、无淋巴结转移中的阳性率分别为77.36%、77.36%,明显高于肿块大小≥2 cm、有淋巴结转移的57.89%、58.18%,差异均有统计学意义(P<0.05);经Spearman相关性分析显示,Ki-67与肿块钙化、毛刺征呈负相关性(P<0.05),Her-2与肿块大小、淋巴结转移呈正相关(P<0.05),PR与后方回声呈正相关(P<0.05),ER与肿块大小呈负相关(P<0.05)。结论乳腺癌患者HFUS超声图像与Ki-67、Her-2、PR、ER表达有一定相关性,对其检测有助于评估患者病情,临床应用价值高。Objective To study the correlation between high frequency ultrasound(HFUS)features and the ex-pression of proliferating cell nuclear antigen(Ki-67),proto oncogene(Her-2),proto oncogene(PR)and estrogen recep-tor(ER)in patients with breast cancer.Methods The clinical data of 110 patients with breast cancer in Shenzhen Bao'an Women's and Children's Hospital from January 2019 to December 2020 were retrospectively analyzed.The HFUS signs and the positive rates of Ki-67,Her-2,PR and ER were recorded.Pearson correlation was used to analyze the correlation between HFUS and Ki-67,Her-2,PR and ER.Results The positive rate of Ki-67,Her-2,PR,ER in breast cancer tissue was 67.27%(74/110),28.18%(31/110),50.91%(56/110),67.27%(74/110),respectively.The posi-tive rate of Ki-67 in the tumor with size≥2 cm,those without microcalcification,and those without burr signs were 77.19%,77.19%,and 80.00%,respectively,which were significantly higher than 56.60%,56.60%,56.67%in the tumor with size<2 cm,with microcalcification,and those with burr signs(P<0.05).The positive rates of Her-2 in the tumor with size≥2 cm,blood flow gradeⅡtoⅢ,and lymph node metastasis were 38.60%,36.51%,and 40.00%,which were significantly higher than 16.98%,17.02%,16.36%of the tumor with size<2 cm,blood flow grade 0-1,and those without lymph node metastasis(P<0.05).The positive rates of PR in the tumor with size<2 cm and in those with rear echo attenu-ation were 62.26%and 73.08%,which were significantly higher than 40.35%and 44.05%of the tumor with≥2 cm and those without rear echo attenuation(P<0.05).The positive rates of ER in tumor with size<2 cm and those without lymph node metastasis were 77.36%and 77.36%,which were significantly higher than 57.89%and 58.18%of the tumor with size≥2 cm and those with lymph node metastasis(P<0.05).Spearman correlation analysis showed that Ki-67 was nega-tively correlated with calcification and spicule sign,HER-2 was positively correlated with tumor size and lymph node metastasis,PR was positively correlated with posteri

关 键 词：乳腺癌 高频超声 增殖细胞核抗原 原癌基因 孕激素受体 雌激素受体 相关性 

分 类 号：R737.9[医药卫生—肿瘤]