成束蛋白1和角蛋白14表达与T1期胃癌伴淋巴结转移的相关性研究  

Correlations between expressions of fascin-1 and keratin 14 proteins and stage T1 gastric cancer complicated with lymph node metastasis

作　　者：刘钰 恽丹玉 姚小燕 夏婷婷[3] LIU Yu;YUN Danyu;YAO Xiaoyan;XIA Tingting(Department of Internal Medicine,Changzhou Medical District of The 904 th Hospital of Joint Service and Support Force of People′s Liberation Army,Changzhou,Jiangsu,213000;Department of Special Diagnosis,Changzhou Medical District of The 904 th Hospital of Joint Service and Support Force of People′s Liberation Army,Changzhou,Jiangsu,213000;Department of Gastroenterology,The First Hospital Affiliated to Soochow University,Suzhou,Jiangsu,215000)

机构地区：[1]中国人民解放军联勤保障部队第904医院常州医疗区内科,江苏常州213000 [2]中国人民解放军联勤保障部队第904医院常州医疗区特诊科,江苏常州213000 [3]苏州大学附属第一医院消化内科,江苏苏州215000

出　　处：《实用临床医药杂志》2021年第13期15-18,23,共5页Journal of Clinical Medicine in Practice

摘　　要：目的探讨消化内镜检查组织成束蛋白1(FSCN1)和角蛋白14(KRT14)表达与T1期胃癌伴淋巴结转移的相关性。方法选择确诊为T1期胃癌患者120例,其中伴淋巴结转移50例为观察组,未发生淋巴结转移70例为对照组。采用免疫组化染色检测组织FSCN1和KRT14阳性表达率,Western-blot法检测组织FSCN1和KRT14相对表达量。结果观察组肿瘤组织FSCN1和KRT14阳性表达率和相对表达量均高于对照组,差异有统计学意义(P<0.05)。组织FSCN1和KRT14表达与肿瘤的分化级别有显著相关性(P<0.05)。结论FSCN1和KRT14表达与早期胃癌的发生和淋巴结转移相关。Objective To explore the correlations between expressions of fascin1(FSCN1),keratin 14(KRT14)proteins detected by digestive endoscopy and stage T1 gastric cancer complicated with lymph node metastasis.Methods A total of 120 patients diagnosed as stage T1 gastric cancer were enrolled,50 patients with lymph node metastasis were selected as observation group,and the other 70 patients without lymph node metastasis were selected as control group.The positive expression rates of tissue FSCN1 and KRT14 were detected by immunohistochemical staining,and relative expressions of FSCN1 and KRT14 were detected by Western-blot.Results The positive expression rates and relative expressions of FSCN1 and KRT14 in the observation group were significantly higher than those in the control group(P<0.05).The expressions of FSCN1 and KRT14 were significantly correlated with differentiation grade of the tumor(P<0.05).Conclusion Expressions of FSCN1 and KRT14 are correlated with occurrence of early gastric cancer and lymph node metastasis.

关 键 词：消化内镜 成束蛋白1 角蛋白14 胃癌 淋巴结转移 

分 类 号：R573.9[医药卫生—消化系统] R735[医药卫生—内科学]