氯丙嗪片与氨磺必利片对精神分裂症患者出院后治疗依从性、生活质量、日常生活能力康复状况的影响  

Effects of Chlorpromazine and Amisulpride Tablets on Treatment Compliance,Quality of Life,and Rehabilitation of Schizophrenia Patients after Discharge

作　　者：谢悦喜[1] 林育波 郑闻华 XIE Yuexi;LIN Yubo;ZHENG Wenhua(Department of Psychiatry,the Fourth People's Hospital of Shantou,Shantou,Guangdong Province,515000 China)

机构地区：[1]汕头市第四人民医院精神科,广东汕头515000

出　　处：《中外医疗》2021年第18期21-24,共4页China & Foreign Medical Treatment

基　　金：汕头市科技计划医疗卫生类别项目(190926225260590)。

摘　　要：目的探讨氯丙嗪片与氨磺必利片治疗对精神分裂症患者出院后治疗依从性、生活质量、日常生活能力康复状况的影响。方法方便选取2017年11月—2019年11月该院收治的精神分裂症患者63例作为研究对象,通过抛硬币法分别分为研究组和对照组。对照组32例患者采取氯丙嗪片单药治疗,研究组31例患者应用氨磺必利片进行治疗,对比两组患者离院后各阶段依从性;通过生活质量综合评定问卷(GQOLI)及生活能力以社会功能评定量表(SSEPI)评分比较患者离院后各阶段生活质量及日常生活能力变化差异。结果两组患者出院时依从性均为100.00%。出院后6个月研究组依从性(96.77%)较对照组(68.75%)明显偏高,差异有统计学意义(χ^(2)=8.581,P<0.05)。出院后12个月研究组依从性(93.54%)较对照组(40.63%)更高,差异有统计学意义(χ^(2)=19.846,P<0.05)。两组患者离院时GQOLI、SSEPI评分差异无统计学意义(P>0.05)。离院后6、12个月研究组患者GQOLI较出院时明显提升,且总体评分值较对照组更高,差异有统计学意义(t=22.109、41.584,P<0.05)。患者离院后6、12个月研究组患者SSEPI评分较出院时明显提升,且总体评分值较对照组更高,差异有统计学意义(t=7.453、31.099,P<0.05)。结论氨磺必利片治疗对精神分裂症患者出院后治疗依从性、生活质量、日常生活能力康复状况改善显著,较氯丙嗪治疗更佳,疗效确切。Objective To investigate the effects of chlorpromazine and amisulpride tablets on treatment compliance,quality of life,and rehabilitation of schizophrenia patients after discharge from the hospital.Methods A total of 63 patients with schizophrenia admitted to the hospital from November 2017 to November 2019 were conveniently selected as the research objects,and they were divided into the study group and the control group by the coin flip method.32 patients in the control group were treated with chlorpromazine tablets alone,and 31 patients in the study group were treated with amisulpride tablets.The compliance of the two groups of patients at various stages after discharge from the hospital was compared;the comprehensive quality of life assessment questionnaire(GQOLI)and Life ability was compared with the social function rating scale(SSEPI)scores to compare the changes in the quality of life and the ability of daily living of patients at various stages after discharge.Results The compliance of the two groups of patients at discharge was 100.00%.The compliance of the study group(96.77%)was significantly higher than the control group(68.75%)6 months after discharge,the difference was statistically significant(χ^(2)=8.581,P<0.05).The compliance of the study group(93.54%)was higher than the control group(40.63%)at 12 months after discharge,the difference was statistically significant(χ^(2)=19.846,P<0.05).There difference was not statistically significant in GQOLI and SSEPI scores between the two groups of patients when they left the hospital(P>0.05).The GQOLI of patients in the study group was significantly higher than that at discharge at 6 and 12 months after discharge,and the overall score was higher than that of the control group,the difference was statistically significant(t=22.109,41.584,P<0.05).The SSEPI score of patients in the study group was significantly higher than that at discharge at 6 and 12 months after the patients were discharged,and the overall score was higher than that of the control group,the d

关 键 词：氯丙嗪 氨磺必利片 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]