注射用A群链球菌治疗食管癌术后胸腔积液的临床观察  

Clinical observation of streptococcus A group for injection in the treatment of pleural effusion after esophageal cancer surgery

作　　者：徐伟[1] 黄伟钊[1] 唐渲[1] XU Wei;HUANG Wei-zhao;TANG Xuan(Department of Cardio-Thoracic Surgery,Zhongshan People’s Hospital,Zhongshan 528403,China)

机构地区：[1]中山市人民医院心胸外科,528403

出　　处：《中国实用医药》2021年第23期10-13,共4页China Practical Medicine

摘　　要：目的探析注射用A群链球菌(商品名:沙培林)治疗食管癌术后胸腔积液患者的效果。方法20例食管癌根治术后胸腔积液患者,随机分为对照组和观察组,每组10例。对照组患者实施经皮穿刺置入导管引流方案治疗,观察组患者在对照组基础上予以注射用A群链球菌治疗。比较两组临床疗效,治疗后不良反应发生情况,症状改善时间,治疗后自然杀伤细胞(NK细胞)活性与T细胞亚群。结果观察组总有效率90.00%显著高于对照组的20.00%,差异具有统计学意义(P<0.05)。观察组治疗后不良反应发生率10.00%显著低于对照组的60.00%,差异具有统计学意义(P<0.05)。观察组胸痛、胸闷、气短改善时间分别为(1.15±0.54)、(1.25±0.64)、(1.31±0.48)d,均显著短于对照组的(3.25±0.45)、(3.57±0.68)、(3.78±0.51)d,差异具有统计学意义(P<0.05)。治疗后,观察组的CD8^(+)为(27.28±0.46)%、CD3^(+)为(55.49±1.41)%均低于对照组的(28.83±2.31)%、(56.31±1.53)%,CD4^(+)为(29.19±2.31)%、CD4^(+)/CD8^(+)为(1.08±0.17)高于对照组的(28.47±0.13)%、(0.98±0.23),但两组比较差异无统计学意义(P>0.05);观察组NK细胞活性(37.99±6.55)%显著高于对照组的(22.26±0.98)%,差异具有统计学意义(P<0.05)。结论食管癌术后胸腔积液患者经注射用A群链球菌治疗后可提升患者临床疗效,降低白细胞减少、发热、恶心呕吐以及胸痛胸闷等不良反应的发生率,改善患者NK细胞活性与T细胞亚群,促使患者病情尽早康复。Objective To discuss and analyze the effect of streptococcus A group for injection(trade name:Sapylin)in the treatment of pleural effusion after esophageal cancer surgery.Methods A total of 20 patients with pleural effusion after esophageal cancer surgery were randomly divided into control group and observation group,with 10 cases in each group.The control group was treated with percutaneous catheter drainage,and the observation group was treated with streptococcus A group for injection based on the control group.The clinical efficacy,occurrence of adverse reactions,symptom improvement time,natural killer cell(NK cell)activity and T cell subsets after treatment were compared between the two groups.Results The total effective rate 90.00%of the observation group was significantly higher than 20.00%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group after treatment was 10.00%,which was significantly lower than 60.00%of the control group,and the difference was statistically significant(P<0.05).The improvement time of chest pain,chest tightness,shortness of breath of the observation group were(1.15±0.54),(1.25±0.64)and(1.31±0.48)d,which were significantly shorter than(3.25±0.45),(3.57±0.68)and(3.78±0.51)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the CD8^(+)(27.28±0.46)%and CD3^(+)(55.49±1.41)%of the observation group were lower than(28.83±2.31)%and(56.31±1.53)%of the control group,and CD4^(+)(29.19±2.31)%and CD4^(+)/CD8^(+)(1.08±0.17)were higher than(28.47±0.13)%(0.98±0.23)and of the control group.All the difference was not statistically significant(P>0.05).The NK cell activity(37.99±6.55)%of the observation group was significantly higher than(22.26±0.98)%of the control group,and the difference was statistically significant(P<0.05).Conclusion Streptococcus A group for injection can significantly improve the clinical efficacy of patients with pleural effusion after e

关 键 词：食管癌 术后胸腔积液 注射用A群链球菌 临床疗效 

分 类 号：R735.1[医药卫生—肿瘤]