425例学前儿童沙门氏菌腹泻临床特征、病原体血清学及耐药性分析  

Clinical characteristics,pathogen serology and drug resistance analysis of 425 cases of Salmonella diarrhea in preschool children

作　　者：张炽伦[1] 谭南[1] 杨晓华[1] 何嘉麟 简晓毅 袁春雷[1] ZHA NGChi-lun;TAN Nan;YANG Xiao-hua(Department of Clinical Laboratory,Boai Hospital,Guangdong Zhongshan 528400)

机构地区：[1]中山市博爱医院检验科,广东中山528400

出　　处：《医学检验与临床》2021年第7期29-32,共4页Medical Laboratory Science and Clinics

摘　　要：目的:分析425例学前儿童沙门氏菌腹泻临床特征,病原体血清学及耐药性。方法:选择我院2017年1月~2019年12月收治的425例沙门氏菌腹泻学前儿童为研究对象,分析其临床特征,检测病原体血清学和耐药性。结果:共收集学前儿童腹泻的标本14938份,检出沙门氏菌株腹泻病426例,检出沙门氏菌株525株,以鼠伤寒沙门氏菌占比率最高。沙门氏菌腹泻患儿中<1岁者占比率最高(P<0.05),<1岁者的大便性状以粘液便及脓血便为主,此类患儿温度>38.5℃率、混合感染率、及平均发热时间高于或多于其他年龄段(P<0.05),学前儿童沙门氏菌腹泻在第二、第三季度的发生率高于第一季度及第四季度(P<0.05)。525株沙门菌对厄他培南、复方新诺明、美罗培南、莫西沙星、哌拉西林、亚胺培南、氧氟沙星完全敏感,对丁胺卡那霉、庆大霉素、妥布霉素完全耐药。结论:学前儿童沙门氏菌腹泻呈低龄化,鼠伤寒沙门氏菌为其优势菌株,高耐药及多重耐药现象较严重。Objective:To analyze the clinical features,pathogen serology and drug resistance of 425 preschool children with Salmonella diarrhea.Methods:425 preschool children with Salmonella diarrhea in our hospital from January 2017 to December 2019 were selected as the research objects,and their clinical characteristics were analyzed,and the serology and drug resistance of pathogens were detected.Results:A total of 14938 samples of diarrhea in preschool children were collected.426 cases of diarrhea infected with Salmonella strains were detected,in which 525 Salmonella strains were isolated,with Salmonella typhimurium accounting for the highest proportion.The proportion of children infected with Salmonella diarrhea was the highest(P<0.05).The stool characteristics in patients of<1 year old were mainly showed mucinous,pus or bloody.These patients had high ratios of temperature>38.5℃,mixed infection,and longer fever time compared with those of other age groups(P<0.05).The incidence of Salmonella diarrhea infection in preschool children in the second and third quarters was higher than that in the first and fourth quarters(P<0.05).The 525 Salmonella strains were completely sensitive to eratapenem,cotrimoxazole,meropenem,moxifloxacin,piperacillin,imipenem,ofloxacin,but resistant to amikanamella,gentamicin,and tobramycin.Conclusion:Patients infected with salmonella in preschool children tends to be younger.Salmonella typhimurium is the dominant strain,and the phenomenon of high drug resistance and multi-drug resistance is serious.

关 键 词：沙门氏菌腹泻 学前儿童 临床特征 病原体血清学 耐药性 

分 类 号：S85[农业科学—兽医学]