微创颅内血肿清除术后局部采用尿激酶对基底节高血压脑出血患者的临床疗效及对神经康复的影响研究  

Clinical Effect of Local Application of Urokinase after Minimally Invasive Evacuation of Intracranial Hematoma on Patients with Hypertensive Cerebral Hemorrhage in Basal Ganglia and its Influence on Neurological Rehabilitation

作　　者：李占忠 LI Zhanzhong(Department of Neurosurgery,Changle People's Hospital,Weifang 262400,China)

机构地区：[1]昌乐县人民医院神经外科,山东潍坊262400

出　　处：《中国医药指南》2021年第20期19-21,共3页Guide of China Medicine

摘　　要：目的探讨微创颅内血肿清除术联合术后尿激酶溶解治疗基底核区高血压脑出血(HICH)的效果及对神经功能、预后的影响研究。方法本次研究对象纳入2019年8月至2020年9月在我院接受治疗的HICH患者86例,结合不同的治疗法分为对照组和观察组,每组43例。两组住院后都接受常规治疗,如吸氧、调节血压和酸碱失衡、脱水降颅压、纠正水电解质紊乱等。并且对患者生命体征进行严格观察,完成术前有关检查。观察组接受微创颅内血肿清除术联合术后尿激酶溶解治疗,对照组接受传统开颅血肿清除去骨瓣减压术法。对比两组的临床疗效,对比两组的并发症状况,对比两组的生活能力。结果观察组的总有效率为88.37%,对照组的总有效率为60.47%,观察组明显比对照组高,差异有统计学意义(P<0.05)。观察组的并发症总发生率为30.23%,对照组的并发症总发生率为53.49%,观察组明显比对照组低,差异有统计学意义(P<0.05)。两组治疗前生活能力评分相对比,无统计学意义(P>0.05);两组经治疗后生活能力评分都比治疗前高,且观察组明显比对照组高(P<0.05),有统计学意义。结论微创颅内血肿清除术联合术后尿激酶溶解治疗基底核区HICH能够使临床治疗效果提高,促进恢复患者的日常生活能力,减少并发症。Objective To investigate the effect of minimally invasive evacuation of intracranial hematoma combined with postoperative urokinase lysis in the treatment of hypertensive intracerebral hemorrhage in basal ganglia and its influence on neurological function and prognosis.Methods The subjects of this study included 86 HICH patients who were treated in our hospital from August 2019 to September 2020.They were divided into a control group and an observation group based on different treatment methods,with 43 cases in each group.Both groups received conventional treatment after hospitalization,such as oxygen inhalation,regulating blood pressure and acid-base imbalance,dehydration to lower intracranial pressure,and correction of water and electrolyte disorders.And strictly observe the patient's vital signs,and complete the preoperative examination.The observation group received minimally invasive intracranial hematoma removal combined with postoperative urokinase dissolution therapy,and the control group received traditional craniotomy hematoma removal and decompressive craniectomy.Compare the clinical efficacy of the two groups;compare the complications of the two groups;compare the living ability of the two groups.Results The total effective rate of the observation group was 88.37%,and the total effective rate of the control group was 60.47%.The observation group was significantly higher than the control group,and the difference was statistically significant(P<0.05).The total incidence of complications in the observation group was 30.23%,and the total incidence of complications in the control group was 53.49%.The observation group was significantly lower than the control group,and the difference was statistically significant(P<0.05).The life abitity scores of the two groups were compared before treatment was no statistically significant(P>0.05);the life abitity scores of the two groups after treatment were higher than those before treatment,and the observation group was significantly higher than the control group(P<0.0

关 键 词：微创 颅内血肿清除术联合 术后 尿激酶溶解 基底核区 高血压脑出血 神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]